Document Detail

Homology modeling and functional annotation of bubaline pregnancy associated glycoprotein 2.
MedLine Citation:
PMID:  22958467     Owner:  NLM     Status:  PubMed-not-MEDLINE    
BACKGROUND: Pregnancy associated glycoproteins form a diverse family of glycoproteins that are variably expressed at different stages of gestation. They are probably involved in immunosuppression of the dam against the feto-maternal placentome. The presence of the products of binucleate cells in maternal circulation has also been correlated with placentogenesis and placental re-modeling. The exact structure and function of the gene product is unknown due to limitations on obtaining purified pregnancy associated glycoprotein preparations.
RESULTS: Our study describes an in silico derived 3D model for bubaline pregnancy associated glycoprotein 2. Structure-activity features of the protein were characterized, and functional studies predict bubaline pregnancy associated glycoprotein 2 as an inducible, extra-cellular, non-essential, N-glycosylated, aspartic pro-endopeptidase that is involved in down-regulation of complement pathway and immunity during pregnancy. The protein is also predicted to be involved in nutritional processes, and apoptotic processes underlying fetal morphogenesis and re-modeling of feto-maternal tissues.
CONCLUSION: The structural and functional annotation of buPAG2 shall allow the designing of mutants and inhibitors for dissection of the exact physiological role of the protein.
Bhaskar Ganguly; Shiv Prasad
Related Documents :
17439527 - Preterm delivery and exposure to active and passive smoking during pregnancy: a case-co...
14742347 - Perinatal outcome of singletons and twins after assisted conception: a systematic revie...
8694047 - Cervical fetal fibronectin in patients at increased risk for preterm delivery.
10819817 - Appendicitis in pregnancy: new information that contradicts long-held clinical beliefs.
1674477 - Invasive techniques for fetal diagnosis in multiple pregnancy.
8284287 - First-trimester biochemical screening for fetal chromosome abnormalities and neural tub...
Publication Detail:
Type:  Journal Article     Date:  2012-05-31
Journal Detail:
Title:  Journal of animal science and biotechnology     Volume:  3     ISSN:  2049-1891     ISO Abbreviation:  J Anim Sci Biotechnol     Publication Date:  2012  
Date Detail:
Created Date:  2012-09-10     Completed Date:  2012-10-02     Revised Date:  2013-04-02    
Medline Journal Info:
Nlm Unique ID:  101581293     Medline TA:  J Anim Sci Biotechnol     Country:  England    
Other Details:
Languages:  eng     Pagination:  13     Citation Subset:  -    
Department of Veterinary Physiology and Biochemistry, College of Veterinary and Animal Sciences, G, B, Pant University of Agriculture and Technology, Pantnagar, PIN: 263145, India.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Descriptors of dyspnea in obstructive lung diseases.
Next Document:  Social 'wanting' dysfunction in autism: neurobiological underpinnings and treatment implications.