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Homology modeling and functional annotation of bubaline pregnancy associated glycoprotein 2.
MedLine Citation:
PMID:  22958467     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Pregnancy associated glycoproteins form a diverse family of glycoproteins that are variably expressed at different stages of gestation. They are probably involved in immunosuppression of the dam against the feto-maternal placentome. The presence of the products of binucleate cells in maternal circulation has also been correlated with placentogenesis and placental re-modeling. The exact structure and function of the gene product is unknown due to limitations on obtaining purified pregnancy associated glycoprotein preparations.
RESULTS: Our study describes an in silico derived 3D model for bubaline pregnancy associated glycoprotein 2. Structure-activity features of the protein were characterized, and functional studies predict bubaline pregnancy associated glycoprotein 2 as an inducible, extra-cellular, non-essential, N-glycosylated, aspartic pro-endopeptidase that is involved in down-regulation of complement pathway and immunity during pregnancy. The protein is also predicted to be involved in nutritional processes, and apoptotic processes underlying fetal morphogenesis and re-modeling of feto-maternal tissues.
CONCLUSION: The structural and functional annotation of buPAG2 shall allow the designing of mutants and inhibitors for dissection of the exact physiological role of the protein.
Authors:
Bhaskar Ganguly; Shiv Prasad
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Publication Detail:
Type:  Journal Article     Date:  2012-05-31
Journal Detail:
Title:  Journal of animal science and biotechnology     Volume:  3     ISSN:  2049-1891     ISO Abbreviation:  J Anim Sci Biotechnol     Publication Date:  2012  
Date Detail:
Created Date:  2012-09-10     Completed Date:  2012-10-02     Revised Date:  2013-04-02    
Medline Journal Info:
Nlm Unique ID:  101581293     Medline TA:  J Anim Sci Biotechnol     Country:  England    
Other Details:
Languages:  eng     Pagination:  13     Citation Subset:  -    
Affiliation:
Department of Veterinary Physiology and Biochemistry, College of Veterinary and Animal Sciences, G, B, Pant University of Agriculture and Technology, Pantnagar, PIN: 263145, India. vetbhaskar@gmail.com.
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