Document Detail


Homografts in aortic position: does blood group incompatibility have an impact on patient outcomes?
MedLine Citation:
PMID:  23390142     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVES: Aortic homografts are an alternative to mechanical or biological valve prostheses. Homografts are generally not transplanted ABO-compatible while this policy is still under debate. The purpose of this study was to investigate whether ABO compatibility impacts on long-term outcomes or not.
METHODS: Between 1992 and 2009, 363 adult patients with a mean age of 52 years received homografts in aortic position. Donor and acceptor blood groups could be obtained for 335 patients. Sixty-three percent received blood group-compatible (n = 212) (Group iso) and 37% non-blood group-compatible allografts (n = 123) (Group non-iso).
RESULTS: The overall event-free survival (freedom from death or reoperation) was 55.5% (n = 186). In the iso group, the event-free survival was 84.1% at 5 years and 63.3% at 10 years. In the non-iso group, the event-free survival was 79.4% at 5 years and 51.8% at 10 years. 28.5% of patients (n = 35) with ABO-incompatible and 25.5% (n = 54) with ABO-compatible grafts required reoperation. The mean time to reoperation in the iso group was 97.3 vs 90 months in the non-iso group.
CONCLUSIONS: In 17 years of research, we have not yet found a statistical significant difference in blood group incompatibility regarding overall event-free survival. In our opinion, there is no need to use ABO-compatible homografts for aortic valve replacement in adults. Histological and immunohistochemical assays are mandatory to confirm our results.
Authors:
Ferdinand Vogt; Bernhard Michael Böll; Anne-Laure Boulesteix; Eckehard Kilian; Giuseppe Santarpino; Bruno Reichart; Christoph Schmitz
Publication Detail:
Type:  Journal Article     Date:  2013-02-06
Journal Detail:
Title:  Interactive cardiovascular and thoracic surgery     Volume:  16     ISSN:  1569-9285     ISO Abbreviation:  Interact Cardiovasc Thorac Surg     Publication Date:  2013 May 
Date Detail:
Created Date:  2013-04-22     Completed Date:  2013-11-04     Revised Date:  2014-05-07    
Medline Journal Info:
Nlm Unique ID:  101158399     Medline TA:  Interact Cardiovasc Thorac Surg     Country:  England    
Other Details:
Languages:  eng     Pagination:  619-24     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
ABO Blood-Group System*
Adolescent
Adult
Aged
Aortic Valve / transplantation*,  ultrasonography
Blood Group Incompatibility / complications*,  mortality,  surgery
Disease-Free Survival
Female
Heart Valve Prosthesis Implantation / adverse effects,  methods*,  mortality
Histocompatibility Testing
Humans
Kaplan-Meier Estimate
Linear Models
Male
Middle Aged
Postoperative Complications / mortality,  surgery
Pulmonary Valve / transplantation*,  ultrasonography
Reoperation
Risk Factors
Time Factors
Transplantation, Homologous
Treatment Outcome
Young Adult
Chemical
Reg. No./Substance:
0/ABO Blood-Group System
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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