| Homogeneity in the relationship of serum cholesterol to coronary deaths across different cultures: 40-year follow-up of the Seven Countries Study. | |
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MedLine Citation:
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PMID: 19050437 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: The aim was to investigate whether multivariate coefficients of serum cholesterol in the prediction of coronary heart disease (CHD) deaths were similar across different cultures in a long-term follow-up. DESIGN: Thirteen cohorts for a total of 10,157 men aged 40-59 years at entry, enrolled in seven countries (USA, Finland, the Netherlands, Italy, Serbia, Greece, Japan) were repeatedly examined and followed up for 40 years. METHODS: Serum cholesterol measured at baseline, and then on repeated occasions, was studied, using multivariate models, in relation with the occurrence of CHD deaths during a 40-year follow-up. RESULTS: Homogeneity of multivariate serum cholesterol coefficients was found considering cholesterol levels at baseline, as average of up to three measurements during the first 10 years, as average of up to six measurements in 35 years, using the time-dependent technique with up to three measurements in 10 years, and with up to six measurement in 35 years. CONCLUSION: The strength of the association between serum cholesterol and CHD death seems homogeneous across different cultures characterized by different levels of serum cholesterol and different absolute risk of CHD death. |
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Authors:
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Alessandro Menotti; Mariapaola Lanti; Daan Kromhout; Henry Blackburn; David Jacobs; Aulikki Nissinen; Anastasios Dontas; Antony Kafatos; Srecko Nedeljkovic; Hisashi Adachi |
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Publication Detail:
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Type: Comparative Study; Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: European journal of cardiovascular prevention and rehabilitation : official journal of the European Society of Cardiology, Working Groups on Epidemiology & Prevention and Cardiac Rehabilitation and Exercise Physiology Volume: 15 ISSN: 1741-8275 ISO Abbreviation: Eur J Cardiovasc Prev Rehabil Publication Date: 2008 Dec |
Date Detail:
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Created Date: 2008-12-08 Completed Date: 2009-04-20 Revised Date: 2011-09-26 |
Medline Journal Info:
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Nlm Unique ID: 101192000 Medline TA: Eur J Cardiovasc Prev Rehabil Country: England |
Other Details:
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Languages: eng Pagination: 719-25 Citation Subset: IM |
Affiliation:
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Association for Cardiac Research, Rome, Italy. menottia@tin.it |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Asian Continental Ancestry Group / statistics & numerical data* Biological Markers / blood Cholesterol / blood* Coronary Disease / blood, ethnology, mortality* Cross-Cultural Comparison* Europe / epidemiology European Continental Ancestry Group / statistics & numerical data* Follow-Up Studies Humans Japan / epidemiology Male Middle Aged Predictive Value of Tests Proportional Hazards Models Risk Assessment Risk Factors Time Factors |
| Grant Support | |
ID/Acronym/Agency:
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R01 HL053560-12/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 57-88-5/Cholesterol |
| Comments/Corrections | |
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