Document Detail


Homodimeric pregnancy-associated plasma protein-A in normal human placenta of first and third trimester of pregnancy: Biochemical and morphological observations.
MedLine Citation:
PMID:  23010598     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Insulin-like growth factors (IGFs) become bio-available following hydrolysis of binding proteins by homodimeric PAPP-A (dPAPP-A); this is a metzincin associated with the membranes of trophoblast phenotypes, the precise placental localization of which was unknown. Our study on placental samples of the first trimester shows the immunohistochemical localization of proMBP and dPAPP-A in the same cells. In contrast, dPAPP-A is mainly negative in the syncytium (ST) and positive in the villous cytotrophoblast (VCT) while htPAPP-A is strongly expressed in the ST and negative in the VCT at term, suggesting a progressive deactivation of the enzyme with gestational age. In agreement with the above, dPAPP-A is released only by first trimester placental explants in culture.
Authors:
P D'Elia; D Marzioni; M Castellucci; C Mocci; A Pala
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-9-22
Journal Detail:
Title:  Placenta     Volume:  -     ISSN:  1532-3102     ISO Abbreviation:  Placenta     Publication Date:  2012 Sep 
Date Detail:
Created Date:  2012-9-26     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8006349     Medline TA:  Placenta     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012 Elsevier Ltd. All rights reserved.
Affiliation:
Laboratory of Biochemistry of Sexual Hormones, Department of Gynaecology, Obstetrics and Urology, University La Sapienza, Viale Regina Elena 328, 00161, Roma, Italy; Department of Chemistry, Faculty of Mathematical Physical and Natural Sciences, University La Sapiena, Piazzale Aldo Moro, Roma, Italy.
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