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Homocysteine and vitamin therapy in stroke prevention and treatment: a review.
MedLine Citation:
PMID:  21140003     Owner:  NLM     Status:  In-Process    
Abstract/OtherAbstract:
Homocysteine (Hcy), a sulfur amino acid, is the only direct precursor for L-methionine synthesis through a reaction that requires vitamin B₁₂, representing a connection with "one-carbon" units metabolism. Hcy catabolism requires vitamin B₆ and as a consequence, alteration in folic acid and B vitamins status impairs Hcy biotransformation. Numerous studies have indicated that Hcy is an independent risk factor for cardio- and cerebrovascular diseases. In the last decade, several clinical trials have investigated the possible correlation between the use of folic acid and vitamins B₆ and B₁₂ for lowering Hcy plasma concentration and the reduced risk of stroke or its recurrence. This review is aimed to present some aspects of Hcy biochemistry, as well as the mechanisms through which it exerts the toxic effects on the vascular endothelium. We also discuss the results of some of the clinical trials developed to investigate the beneficial effects of vitamin therapy in the prevention and management of stroke.
Authors:
Bogdan N Manolescu; Eliza Oprea; Ileana C Farcasanu; Mihai Berteanu; Cornelia Cercasov
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Publication Detail:
Type:  Journal Article     Date:  2010-12-06
Journal Detail:
Title:  Acta biochimica Polonica     Volume:  57     ISSN:  1734-154X     ISO Abbreviation:  Acta Biochim. Pol.     Publication Date:  2010  
Date Detail:
Created Date:  2010-12-30     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  14520300R     Medline TA:  Acta Biochim Pol     Country:  Poland    
Other Details:
Languages:  eng     Pagination:  467-77     Citation Subset:  IM    
Affiliation:
Department of Biochemistry, University of Medicine and Pharmacy "Carol Davila", Bucharest, Romania. manolescub@yahoo.fr
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