Document Detail


Homocysteine, vitamin B12, serum and erythrocyte folate in peritoneal dialysis patients.
MedLine Citation:
PMID:  11334318     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Plasma homocysteine (tHcy) is an important risk factor for atherosclerosis in dialysis patients. Few data were reported on the prevalence and severity of hyperhomocysteinemia in peritoneal dialysis (PD) patients. In addition, little attention was paid to the search of factors possibly involved in the pathogenesis of hyperhomocysteinemia in these patients. A cross-sectional study was performed in 107 stable PD patients. None of them was given folate or vitamin B12 supplementation before or during the study. Plasma tHcy, serum vitamin B12, serum and erythrocyte folate were measured by immunoenzymatic methods. Genetic analysis of the methylentetrahydrofolate-reductase thermolabile mutation (tMTHFR) was performed in 61 patients. 97% of patients had tHcy levels higher than normal. tHcy was not different between men and women, patients with or without malnutrition, with or without clinically evident atherosclerotic vasculopathy, with or without anemia. tHcy levels were significantly higher in homozygotes for the tMTHFR mutation than in patients carrying the wild type form. Significant univariate correlation was found between hyperhomocysteinemia and time since the start of dialysis, serum and erythrocyte folate and vitamin B12. The best fitted model equation was log tHcy = 108.53 + 0.1606 (duration of dialysis) -1.1053 (s-F) -0.7980 (age) 0.0215 (vitamin B12). Our results agree with those reported by other authors in hemodialysis patients. Despite the large number of PD patients with normal serum vitamin B12 and folate status, the relation between tHcy and vitamin B12 or folate suggests that the supplementation of these vitamins could be useful irrespective of their serum levels, especially in younger patients or in those treated for a long period of time with peritoneal dialysis.
Authors:
A F De Vecchi; F Bamonti-Catena; S Finazzi; C Patrosso; E Taioli; C Novembrino; P Colucci; G Lando; M De Franceschi; A Marocchi; A T Maiolo
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Clinical nephrology     Volume:  55     ISSN:  0301-0430     ISO Abbreviation:  Clin. Nephrol.     Publication Date:  2001 Apr 
Date Detail:
Created Date:  2001-05-03     Completed Date:  2001-09-06     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  0364441     Medline TA:  Clin Nephrol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  313-7     Citation Subset:  IM    
Affiliation:
Divisione di Nefrologia e Dialisi, IRCCS Ospedale Maggiore, Milano, Italy. deveccpd@polic.cliea.it
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MeSH Terms
Descriptor/Qualifier:
Aged
Cross-Sectional Studies
Erythrocytes / chemistry*
Female
Folic Acid / blood*
Homocysteine / blood*
Homozygote
Humans
Hyperhomocysteinemia / diagnosis,  etiology,  genetics
Male
Methylenetetrahydrofolate Reductase (NADPH2)
Middle Aged
Mutation
Oxidoreductases Acting on CH-NH Group Donors / genetics
Peritoneal Dialysis* / adverse effects
Vitamin B 12 / blood*
Chemical
Reg. No./Substance:
454-28-4/Homocysteine; 59-30-3/Folic Acid; 68-19-9/Vitamin B 12; EC 1.5.-/Oxidoreductases Acting on CH-NH Group Donors; EC 1.5.1.20/Methylenetetrahydrofolate Reductase (NADPH2)

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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