| Homocysteine is transported by the microvillous plasma membrane of human placenta. | |
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MedLine Citation:
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PMID: 20567909 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Elevated maternal plasma concentrations of homocysteine (Hcy) are associated with pregnancy complications and adverse neonatal outcomes. The postulate that we wish to advance here is that placental transport of Hcy, by competing with endogenous amino acids for transporter activity, may account for some of the damaging impacts of Hcy on placental metabolism and function as well as fetal development. In this article, we provide an overview of some recent studies characterising the transport mechanisms for Hcy across the microvillous plasma membrane (MVM) of the syncytiotrophoblast, the transporting epithelium of human placenta. Three Hcy transport systems have been identified, systems L, A and y(+)L. This was accomplished using a strategy of competitive inhibition to investigate the effects of Hcy on the uptake of well-characterised radiolabelled substrates for each transport system into isolated MVM vesicles. The reverse experiments were also performed, examining the effects of model substrates on [³⁵S]L-Hcy uptake. This article describes the evidence for systems L, A and y(+)L involvement in placental Hcy transport and discusses the physiological implications of these findings with respect to placental function and fetal development. |
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Authors:
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Eleni Tsitsiou; Colin P Sibley; Stephen W D'Souza; Otilia Catanescu; Donald W Jacobsen; Jocelyn D Glazier |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review Date: 2010-06-22 |
Journal Detail:
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Title: Journal of inherited metabolic disease Volume: 34 ISSN: 1573-2665 ISO Abbreviation: J. Inherit. Metab. Dis. Publication Date: 2011 Feb |
Date Detail:
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Created Date: 2011-01-25 Completed Date: 2011-05-12 Revised Date: 2011-08-01 |
Medline Journal Info:
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Nlm Unique ID: 7910918 Medline TA: J Inherit Metab Dis Country: Netherlands |
Other Details:
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Languages: eng Pagination: 57-65 Citation Subset: IM |
Affiliation:
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Maternal and Fetal Health Research Group, School of Biomedicine, University of Manchester, Manchester Academic Health Science Centre, St Mary's Hospital, Oxford Road, Manchester, UK. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Amino Acid Transport System A
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metabolism,
physiology Amino Acid Transport System L / metabolism, physiology Amino Acid Transport System y+L / metabolism, physiology Biological Transport Cell Membrane / metabolism* Female Homocysteine / metabolism*, pharmacokinetics Humans Microvilli / metabolism*, ultrastructure Models, Biological Placenta / metabolism*, ultrastructure Pregnancy Sulfur Radioisotopes / pharmacokinetics |
| Grant Support | |
ID/Acronym/Agency:
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G0500647//Medical Research Council; HL52234/HL/NHLBI NIH HHS; R37 HL052234-16/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Amino Acid Transport System A; 0/Amino Acid Transport System L; 0/Amino Acid Transport System y+L; 0/Sulfur Radioisotopes; 454-28-4/Homocysteine |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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