Document Detail


Homocysteine to hydrogen sulfide or hypertension.
MedLine Citation:
PMID:  20387006     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Hyperhomocysteinemia, an increased level of plasma homocysteine, is an independent risk factor for the development of premature arterial fibrosis with peripheral and cerebro-vascular, neurogenic and hypertensive heart disease, coronary occlusion and myocardial infarction, as well as venous thromboembolism. It is reported that hyperhomocysteinemia causes vascular dysfunction by two major routes: (1) increasing blood pressure and, (2) impairing the vasorelaxation activity of endothelial-derived nitric oxide. The homocysteine activates metalloproteinases and induces collagen synthesis and causes imbalances of elastin/collagen ratio which compromise vascular elastance. The metabolites from hyperhomocysteinemic endothelium could modify components of the underlying muscle cells, leading to vascular dysfunction and hypertension. Homocysteine metabolizes in the body to produce H(2)S, which is a strong antioxidant and vasorelaxation factor. At an elevated level, homocysteine inactivates proteins by homocysteinylation including its endogenous metabolizing enzyme, cystathionine gamma-lyase. Thus, reduced production of H(2)S during hyperhomocysteinemia exemplifies hypertension and vascular diseases. In light of the present information, this review focuses on the mechanism of hyperhomocysteinemia-associated hypertension and highlights the novel modulatory role of H(2)S to ameliorate hypertension.
Authors:
Utpal Sen; Paras K Mishra; Neetu Tyagi; Suresh C Tyagi
Related Documents :
9730856 - Nitric oxide synthase activity is increased in relation to the severity of liver dysfun...
15840766 - Trimetazidine normalizes postischemic function of hypertrophied rat hearts.
22645806 - Pressure pain threshold of mucosa after tooth extraction under removable denture bases.
11256976 - Nitric oxide modulation of blood vessel tone identified by arterial waveform analysis.
19854286 - Brood predation pressure during parental care does not influence parental enzyme activi...
16825276 - Glaucoma progression is associated with decreased blood flow velocities in the short po...
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review    
Journal Detail:
Title:  Cell biochemistry and biophysics     Volume:  57     ISSN:  1559-0283     ISO Abbreviation:  Cell Biochem. Biophys.     Publication Date:  2010 Jul 
Date Detail:
Created Date:  2010-06-28     Completed Date:  2010-09-29     Revised Date:  2013-05-29    
Medline Journal Info:
Nlm Unique ID:  9701934     Medline TA:  Cell Biochem Biophys     Country:  United States    
Other Details:
Languages:  eng     Pagination:  49-58     Citation Subset:  IM    
Affiliation:
Department of Physiology & Biophysics, University of Louisville School of Medicine, 500 South Preston Street, Louisville, KY 40202, USA. u0sen001@louisville.edu
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Calcium / metabolism
Collagen / metabolism
Homocysteine / blood*
Humans
Hydrogen Sulfide / metabolism*
Hyperhomocysteinemia / complications,  metabolism
Hypertension / etiology*
Muscle, Smooth, Vascular / cytology,  metabolism
Nitric Oxide / metabolism
Grant Support
ID/Acronym/Agency:
HL-71010/HL/NHLBI NIH HHS; HL-74185/HL/NHLBI NIH HHS; HL-88012/HL/NHLBI NIH HHS; NS-51568/NS/NINDS NIH HHS; R01 HL071010-08/HL/NHLBI NIH HHS; R01 HL074185-07/HL/NHLBI NIH HHS; R01 HL088012-04/HL/NHLBI NIH HHS; R01 NS051568-04/NS/NINDS NIH HHS
Chemical
Reg. No./Substance:
10102-43-9/Nitric Oxide; 454-28-4/Homocysteine; 7440-70-2/Calcium; 7783-06-4/Hydrogen Sulfide; 9007-34-5/Collagen
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Histological lesion of spleen and inhibition of splenocyte proliferation in broilers fed on diets ex...
Next Document:  Comparison of intestinal warm ischemic injury in PACAP knockout and wild-type mice.