| Homocysteine to hydrogen sulfide or hypertension. | |
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MedLine Citation:
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PMID: 20387006 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Hyperhomocysteinemia, an increased level of plasma homocysteine, is an independent risk factor for the development of premature arterial fibrosis with peripheral and cerebro-vascular, neurogenic and hypertensive heart disease, coronary occlusion and myocardial infarction, as well as venous thromboembolism. It is reported that hyperhomocysteinemia causes vascular dysfunction by two major routes: (1) increasing blood pressure and, (2) impairing the vasorelaxation activity of endothelial-derived nitric oxide. The homocysteine activates metalloproteinases and induces collagen synthesis and causes imbalances of elastin/collagen ratio which compromise vascular elastance. The metabolites from hyperhomocysteinemic endothelium could modify components of the underlying muscle cells, leading to vascular dysfunction and hypertension. Homocysteine metabolizes in the body to produce H(2)S, which is a strong antioxidant and vasorelaxation factor. At an elevated level, homocysteine inactivates proteins by homocysteinylation including its endogenous metabolizing enzyme, cystathionine gamma-lyase. Thus, reduced production of H(2)S during hyperhomocysteinemia exemplifies hypertension and vascular diseases. In light of the present information, this review focuses on the mechanism of hyperhomocysteinemia-associated hypertension and highlights the novel modulatory role of H(2)S to ameliorate hypertension. |
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Authors:
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Utpal Sen; Paras K Mishra; Neetu Tyagi; Suresh C Tyagi |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Review |
Journal Detail:
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Title: Cell biochemistry and biophysics Volume: 57 ISSN: 1559-0283 ISO Abbreviation: Cell Biochem. Biophys. Publication Date: 2010 Jul |
Date Detail:
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Created Date: 2010-06-28 Completed Date: 2010-09-29 Revised Date: 2010-09-30 |
Medline Journal Info:
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Nlm Unique ID: 9701934 Medline TA: Cell Biochem Biophys Country: United States |
Other Details:
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Languages: eng Pagination: 49-58 Citation Subset: IM |
Affiliation:
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Department of Physiology & Biophysics, University of Louisville School of Medicine, 500 South Preston Street, Louisville, KY 40202, USA. u0sen001@louisville.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Calcium
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metabolism Collagen / metabolism Homocysteine / blood* Humans Hydrogen Sulfide / metabolism* Hyperhomocysteinemia / complications, metabolism Hypertension / etiology* Muscle, Smooth, Vascular / cytology, metabolism Nitric Oxide / metabolism |
| Grant Support | |
ID/Acronym/Agency:
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HL-71010/HL/NHLBI NIH HHS; HL-74185/HL/NHLBI NIH HHS; HL-88012/HL/NHLBI NIH HHS; NS-51568/NS/NINDS NIH HHS; R01 HL071010-08/HL/NHLBI NIH HHS; R01 HL074185-07/HL/NHLBI NIH HHS; R01 HL088012-04/HL/NHLBI NIH HHS; R01 NS051568-04/NS/NINDS NIH HHS |
| Chemical | |
Reg. No./Substance:
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10102-43-9/Nitric Oxide; 454-28-4/Homocysteine; 7440-70-2/Calcium; 7783-06-4/Hydrogen Sulfide; 9007-34-5/Collagen |
| Comments/Corrections | |
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