Document Detail

Homocysteine and other plasma amino acids in preeclampsia and in pregnancies without complications.
MedLine Citation:
PMID:  12726926     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: To evaluate a). the plasma amino acid changes observed in pregnant women (n = 124) and b). the homocysteine and other amino acid changes in preeclampsic patients (n = 18), and to determine c) whether these changes were also evident in nonpregnant women with a prior history of preeclampsia (n = 18). DESIGN AND METHODS: Case-control study. Plasma total homocysteine (tHcy): HPLC with fluorescence detection, and amino acids (AA): ion exchange chromatography. RESULTS: a). Significantly lower absolute AA values were observed in the pregnant controls for homocysteine, total, essential, and nonessential AA compared with nonpregnant controls. b. In preeclampsia, significantly higher absolute values of tHcy, total, essential and nonessential AA were observed, but relative values referred to total AA were not different. These changes corrected after delivery. CONCLUSIONS: Hyperhomocysteinemia and an increase in most AA levels were observed in preeclampsia. Relative AA values suggested that these changes might be explained by fluctuations in plasma volume. Abnormal AA levels corrected after delivery.
Eva López-Quesada; Maria Antònia Vilaseca; Rafael Artuch; Elena Gómez; Josep M Lailla
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Clinical biochemistry     Volume:  36     ISSN:  0009-9120     ISO Abbreviation:  Clin. Biochem.     Publication Date:  2003 May 
Date Detail:
Created Date:  2003-05-02     Completed Date:  2003-12-18     Revised Date:  2009-11-03    
Medline Journal Info:
Nlm Unique ID:  0133660     Medline TA:  Clin Biochem     Country:  United States    
Other Details:
Languages:  eng     Pagination:  185-92     Citation Subset:  IM    
Department of Obstetrics and Gynecology, Hospital Sant Joan de Déu, University of Barcelona, Barcelona, Spain.
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MeSH Terms
Amino Acids / blood*
Case-Control Studies
Chromatography, High Pressure Liquid
Chromatography, Ion Exchange
Data Interpretation, Statistical
Folic Acid / blood
Homocysteine / blood*
Pre-Eclampsia / blood,  metabolism*
Pregnancy Trimester, Second
Pregnancy Trimester, Third
Vitamin B 12 / blood
Reg. No./Substance:
0/Amino Acids; 454-28-4/Homocysteine; 59-30-3/Folic Acid; 68-19-9/Vitamin B 12

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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