| Homocysteine and other plasma amino acids in preeclampsia and in pregnancies without complications. | |
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MedLine Citation:
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PMID: 12726926 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVES: To evaluate a). the plasma amino acid changes observed in pregnant women (n = 124) and b). the homocysteine and other amino acid changes in preeclampsic patients (n = 18), and to determine c) whether these changes were also evident in nonpregnant women with a prior history of preeclampsia (n = 18). DESIGN AND METHODS: Case-control study. Plasma total homocysteine (tHcy): HPLC with fluorescence detection, and amino acids (AA): ion exchange chromatography. RESULTS: a). Significantly lower absolute AA values were observed in the pregnant controls for homocysteine, total, essential, and nonessential AA compared with nonpregnant controls. b. In preeclampsia, significantly higher absolute values of tHcy, total, essential and nonessential AA were observed, but relative values referred to total AA were not different. These changes corrected after delivery. CONCLUSIONS: Hyperhomocysteinemia and an increase in most AA levels were observed in preeclampsia. Relative AA values suggested that these changes might be explained by fluctuations in plasma volume. Abnormal AA levels corrected after delivery. |
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Authors:
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Eva López-Quesada; Maria Antònia Vilaseca; Rafael Artuch; Elena Gómez; Josep M Lailla |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Clinical biochemistry Volume: 36 ISSN: 0009-9120 ISO Abbreviation: Clin. Biochem. Publication Date: 2003 May |
Date Detail:
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Created Date: 2003-05-02 Completed Date: 2003-12-18 Revised Date: 2009-11-03 |
Medline Journal Info:
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Nlm Unique ID: 0133660 Medline TA: Clin Biochem Country: United States |
Other Details:
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Languages: eng Pagination: 185-92 Citation Subset: IM |
Affiliation:
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Department of Obstetrics and Gynecology, Hospital Sant Joan de Déu, University of Barcelona, Barcelona, Spain. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Amino Acids / blood* Case-Control Studies Chromatography, High Pressure Liquid Chromatography, Ion Exchange Data Interpretation, Statistical Female Folic Acid / blood Homocysteine / blood* Humans Pre-Eclampsia / blood, metabolism* Pregnancy Pregnancy Trimester, Second Pregnancy Trimester, Third Vitamin B 12 / blood |
| Chemical | |
Reg. No./Substance:
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0/Amino Acids; 454-28-4/Homocysteine; 59-30-3/Folic Acid; 68-19-9/Vitamin B 12 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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