| Homocysteine levels and the metabolic syndrome in a Mediterranean population: a case-control study. | |
| | |
MedLine Citation:
|
PMID: 21321409 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Hyperhomocysteinemia (HH) and metabolic syndrome (MS) are associated with increased cardiovascular risk. However, whether there is a link between MS or its components and homocysteine levels in a population without cardiovascular disease is not well established. We conducted a case-control study in 61 MS patients (41 males, 20 females, aged 51 ± 11 years) and in 98 controls without MS (59 males, 39 females, aged 50 ± 10 years) to ascertain the association between MS and HH, and with inflammatory markers. MS was classified according to the updated ATPIII criteria [17]. No differences in homocysteine levels were observed when comparing MS patients and controls (12.0 ± 3.18 μM vs. 11.9 ± 3.5 μM, p = 0.829). No association was found between HH (homocysteine >15 μM) and MS, its components (abdominal obesity (p = 0.635), hypertension (0.229), low-HDL cholesterol (p = 0.491), glucose >100 mg/dL (0.485), hypertriglyceridemia (p = 0.490)) or the number of MS components (p = 272). When considering glucose >110 mg/dL (NCEP-ATPIII criteria, 2001) instead of glucose intolerancen >100 mg/dl (updated ATPIII criteria, Grundy, 2005), a borderline association with HH was observed (p = 0.054) of statistical significance (p = 0.008) when glucose >126 mg/dL was considered. In a multivariate regression model, creatinine, folic acid and vitamin B12 were the only independent predictors of homocysteine levels (p < 0.05). Although MS correlated with inflammatory parameters (fibrinogen, hs-RCP, plasma viscosity and leukocyte count, p < 0.001), no association was found between HH and the above-mentioned parameters (p > 0.05). Our results do not indicate a link between SM or its individual components with HH, and diabetes was the only relevant contribution. Cardiovascular disease risk due to MS and HH seems to share no common mechanisms. |
| | |
Authors:
|
Amparo Vayá; Pilar Carmona; Natalia Badia; Rafael Pérez; Antonio Hernandez Mijares; Dolores Corella |
Related Documents
:
|
1516499 - Effect of glycemic control on growth velocity in children with iddm. 22768899 - The role of self-monitoring of blood glucose in glucagon-like peptide-1-based treatment... 1320459 - Insulin and progesterone increase 32po4-labeling of phospholipids and inositol 1,4,5-tr... 17550219 - Development of diabetes mellitus in two boys after the initiation of growth hormone the... 2958269 - Inhibition of somatomedin-like activity by serum from streptozotocin-diabetic rats: pre... 22411919 - Dipeptidyl peptidase-4 inhibitors for treatment of type 2 diabetes mellitus in the clin... 20852089 - Rapid reduction of severely elevated serum triglycerides with insulin infusion, gemfibr... 16054099 - Prevention of hepatic steatosis and hepatic insulin resistance in mitochondrial acyl-co... 4017199 - Diabetes-induced alterations in the translational activity of specific messenger ribonu... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Clinical hemorheology and microcirculation Volume: 47 ISSN: 1875-8622 ISO Abbreviation: Clin. Hemorheol. Microcirc. Publication Date: 2011 |
Date Detail:
|
Created Date: 2011-02-15 Completed Date: 2011-05-24 Revised Date: 2012-01-31 |
Medline Journal Info:
|
Nlm Unique ID: 9709206 Medline TA: Clin Hemorheol Microcirc Country: Netherlands |
Other Details:
|
Languages: eng Pagination: 59-66 Citation Subset: IM |
Affiliation:
|
Hemorheology and Hemostasis Unit, Service of Clinical Pathology, La Fe University Hospital, Valencia, Spain. vaya amp@gva.es |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Cardiovascular Diseases / etiology* Case-Control Studies Female Homocysteine / blood* Humans Hyperhomocysteinemia / blood, complications* Male Metabolic Syndrome X / blood, complications* Middle Aged |
| Chemical | |
Reg. No./Substance:
|
454-28-4/Homocysteine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Hyperhomocysteinemia, obesity and cryptogenic stroke.
Next Document: The effect of aging on blood and plasma viscosity. An 11.6 years follow-up study.