Document Detail

Homocysteine levels in patients with Beh??et's disease and patients with recurrent aphthous stomatitis.
MedLine Citation:
PMID:  19575262     Owner:  NLM     Status:  MEDLINE    
The mechanism for vascular involvement of Beh??et disease (BD) includes arterial and venous thrombosis. Although the exact etiology of systemic vasculitis and thrombosis is still unknown, many hypotheses have been suggested. One of these hypotheses is that hyperhomocysteinemia causes vascular disease and thrombosis. The aim of this study was to compare the levels of homocysteine, vitamin B(12), and folic acid of BD patients with those of recurrent aphthous stomatitis (RAS) patients and healthy controls. Forty-five BD patients, 47 RAS patients, and 69 healty control subjects were included in this study. Vitamin B(12), folic acid, and homocysteine levels of the patients and controls were measured, and statistical differences among the groups were determined. BD patients had mostly cutaneous symptoms. Arthritis and ocular and vascular involvement were seen in 24.4%, 22%, and 11% of BD patients, respectively. No significant difference was detected among the groups in the levels of vitamin B(12), folic acid, and homocysteine. There was no significant difference in any parameters according to sex and age of the patients and activity of BD and if the patients with BD were treated or not. Homocysteine level inversely correlated with vitamin B(12) and folic acid levels in the BD group. We could not find any differences in homocysteine, vitamin B(12), and folic acid levels between BD and RAS patients and controls. This may be due to the fact that our patients mostly had cutaneous symptoms rather than vascular involvement.
M??zeyyen G??n??l; Ulker G??l; Cumhur Kilin??; Seray K??lc?? Cakmak; Se??il Soylu; Arzu Kili??
Publication Detail:
Type:  Journal Article     Date:  2009-07-03
Journal Detail:
Title:  Clinical rheumatology     Volume:  28     ISSN:  1434-9949     ISO Abbreviation:  Clin. Rheumatol.     Publication Date:  2009 Oct 
Date Detail:
Created Date:  2009-09-03     Completed Date:  2010-01-18     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8211469     Medline TA:  Clin Rheumatol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  1153-6     Citation Subset:  IM    
2nd Dermatology Clinic, Ankara Numune Education and Research Hospital, Ankara, Turkey.
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MeSH Terms
Behcet Syndrome / blood*,  etiology
Biological Markers / blood
Case-Control Studies
Folic Acid / blood
Homocysteine / blood*
Middle Aged
Stomatitis, Aphthous / blood*,  etiology
Vitamin B 12 / blood
Young Adult
Reg. No./Substance:
0/Biological Markers; 454-28-4/Homocysteine; 59-30-3/Folic Acid; 68-19-9/Vitamin B 12

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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