Document Detail

Homocysteine levels in amniotic fluid. Relationship with birth-weight.
MedLine Citation:
PMID:  16601832     Owner:  NLM     Status:  MEDLINE    
Hyperhomocysteinemia could play a similar role in the placenta to that played in adults at risk of thrombosis. Moreover, hyperhomocysteinemia in women is described to be associated with the birth of small for gestational age (SGA) newborns, although there are discrepancies on this issue. To date, there is no biochemical marker predictive of SGA in a given pregnancy. We verified the presence of a relationship between homocysteine in amniotic fluid at mid-pregnancy and birth-weight. Amniotic fluid was obtained from 459 healthy women undergoing midtrimester amniocentesis (17.1 +/- 1.2 weeks) because of maternal age. Homocysteine levels were measured in 434 (10 twin) pregnancies. In addition, femur length (FL) and biparietal diameter (BPD) were measured. Outcome of pregnancy was recorded. 233 (53.7%) foetuses were males, 201 (46.3%) females. The mean homocysteine concentration was 1.04 +/- 0.72 microM, (95% C.I. 0.43-2.41). An univariate analysis showed the presence of an association with gestational age, FL, BPD. A multiple linear regression showed that homocysteine levels were significantly associated with FL (p < 0.001) and BPD (p = 0.011). After excluding twin pregnancies, 31 newborns (7.3%) were classified as SGA. Mean birth-weight was 2390 g in SGA, whereas it was 3360 g in 393 adequate for gestational age (AGA) newborns (p < 0.001). The adjusted mean level of homocysteine was significantly lower in AGA (1.01 microM; 95% C.I: 0.94-1.08) than that recorded in pregnancies resulting in a SGA (1.29 microM; 95% CI: 1.05-1.51; p = 0.03). In a large setting, these data provide reference values for homocysteine in amniotic fluids. Moreover, they suggest that homocysteine levels in amniotic fluids may be higher in pregnancies with a SGA newborn.
Elvira Grandone; Donatella Colaizzo; Gennaro Vecchione; Natale Sciannamè; Angelo Notarangelo; Anna Irma Croce; Maurizio Margaglione
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Thrombosis and haemostasis     Volume:  95     ISSN:  0340-6245     ISO Abbreviation:  Thromb. Haemost.     Publication Date:  2006 Apr 
Date Detail:
Created Date:  2006-04-07     Completed Date:  2006-06-22     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7608063     Medline TA:  Thromb Haemost     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  625-8     Citation Subset:  IM    
Unità di Aterosclerosi e Trombosi, Poliambulatorio Giovanni Paolo II, IRCCS Casa Sollievo della Sofferenza S. Giovanni R. (FG), 71013 Italy.
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MeSH Terms
Amniotic Fluid / metabolism*
Birth Weight
Chromosome Aberrations
Homocysteine / biosynthesis*
Hyperhomocysteinemia / diagnosis,  metabolism
Infant, Newborn
Infant, Small for Gestational Age
Pregnancy Outcome
Prenatal Diagnosis
Reg. No./Substance:

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