Document Detail


Homocysteine levels in adolescent schizophrenia patients.
MedLine Citation:
PMID:  16647249     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Homocysteine is a sulfur containing amino acid that has been widely investigated for its putative role in cardiovascular and neuropsychiatric disorders. It has been suggested that homocysteine has implications especially in young, male schizophrenia patients. In this prospective case-control study, we compared plasma homocysteine levels in a group of adolescent schizophrenia inpatients (aged 14-21 years; n=23) to normal healthy controls (n=51). Mean plasma homocysteine levels were significantly higher in the patient group than in the control group (15.40+/-2.00 and 9.78+/-0.33 micromol/L, respectively, p<0.032). The difference was almost entirely attributable to the male schizophrenia subgroup (18.18+/-5.65 in male patients vs. 10.31+/-5.33 micromol/L in female patients). The group x sex interaction was statistically significant (p=0.0035). These data indicate that a subgroup of male adolescent schizophrenia patients has high homocysteine blood levels. The role of homocysteine in the pathophysiology of adolescent-onset schizophrenia merits further investigation.
Authors:
G Adler Nevo; S Meged; B A Sela; A Hanoch-Levi; R Hershko; A Weizman
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Publication Detail:
Type:  Comparative Study; Journal Article     Date:  2006-04-27
Journal Detail:
Title:  European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology     Volume:  16     ISSN:  0924-977X     ISO Abbreviation:  Eur Neuropsychopharmacol     Publication Date:  2006 Dec 
Date Detail:
Created Date:  2006-11-20     Completed Date:  2007-02-20     Revised Date:  2007-04-20    
Medline Journal Info:
Nlm Unique ID:  9111390     Medline TA:  Eur Neuropsychopharmacol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  588-91     Citation Subset:  IM    
Affiliation:
The Hospital for Sick Children and the University of Toronto, Toronto, Canada. gili.adlernevo@sickkids.ca
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Analysis of Variance
Case-Control Studies
Chromatography, High Pressure Liquid / methods
Female
Homocysteine / blood*
Humans
Male
Prospective Studies
Schizophrenia / blood*
Chemical
Reg. No./Substance:
454-28-4/Homocysteine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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