Document Detail


Homocysteine levels, haemostatic risk factors and patency rates after endovascular treatment of the common iliac arteries.
MedLine Citation:
PMID:  16325435     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVES: To investigate the impact of clinical risk factors, plasma homocysteine and haemostatic variables on the results after endovascular treatment of symptomatic atherosclerosis of the common iliac artery. DESIGN: Prospective observational study. SETTING: University hospital. PATIENTS AND METHOD: The study included 139 technically successful interventions in 103 patients. Technical success was defined as < or = 30% residual stenosis as seen on the post treatment angiogram. Blood samples for analyses of fasting plasma values of homocysteine, fibrinogen, D-dimer, activated protein C resistance were drawn upon admission. Median follow-up for all procedures was 22 months (range 0-55 months). Patency was defined as freedom from > or = 50% restenosis or reocclusion. RESULTS: The technical success rate for all procedures was 93%. The 1-year cumulative primary patency rate based on intention to treat was 85%. Multivariate analysis revealed a significant independent association between patency rates and levels of fibrinogen and homocysteine and the nature of the lesion treated (stenosis vs. occlusion). CONCLUSION: The aetiology of restenoses and reocclusions is probably multifactorial. Procoagulant activity, the nature of the lesion treated and homocysteine levels within and above the upper range of normal limits are important risk factors for failure after endovascular treatment of the common iliac arteries.
Authors:
E Laxdal; J Wirsching; G Pedersen; A Bertz; S R Amundsen; E Dregelid; T Jonung; T Nyheim; S Aune
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Publication Detail:
Type:  Journal Article     Date:  2005-12-01
Journal Detail:
Title:  European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery     Volume:  31     ISSN:  1078-5884     ISO Abbreviation:  Eur J Vasc Endovasc Surg     Publication Date:  2006 Mar 
Date Detail:
Created Date:  2006-02-27     Completed Date:  2006-04-25     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9512728     Medline TA:  Eur J Vasc Endovasc Surg     Country:  England    
Other Details:
Languages:  eng     Pagination:  244-50     Citation Subset:  IM    
Affiliation:
Department of Vascular Surgery, Haukeland University Hospital, Bergen, Norway. elin.laxdal@helse-bergen.no
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Aged, 80 and over
Angioplasty, Balloon*
Atherosclerosis / therapy*
Female
Fibrin Fibrinogen Degradation Products / analysis*
Fibrinogen / analysis*
Graft Occlusion, Vascular / blood,  epidemiology*
Hemostasis
Homocysteine / blood*
Humans
Iliac Artery* / surgery
Male
Middle Aged
Multivariate Analysis
Risk Factors
Stents
Treatment Outcome
Vascular Patency* / physiology
Vascular Surgical Procedures*
Chemical
Reg. No./Substance:
0/Fibrin Fibrinogen Degradation Products; 0/fibrin fragment D; 454-28-4/Homocysteine; 9001-32-5/Fibrinogen

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