Document Detail


Homocysteine induces inflammatory transcriptional signaling in monocytes.
MedLine Citation:
PMID:  23276953     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Hyperhomocysteinemia (HHcy) is an independent risk factor for cardiovascular disease. Here, we studied transcriptional regulation in homocysteine (Hcy)-induced gene expression in monocytes (MC). We identified 11 Hcy-induced genes, 17 anti-inflammatory cytokine interleukin 10-induced, 8 pro-inflammatory cytokine interferon gamma (IFN gamma)-induced and 8 pro-inflammatory cytokine tumor necrosis factor alpha (TNF alpha)-induced genes through literature search. Binding frequency of 36 transcription factors (TFs) implicated in inflammation and MC differentiation were analyzed within core promoter regions of identified genes, and classified into 3 classes based on the significant binding frequency to the promoter of Hcy-induced genes. Class 1 TFs exert high significant binding frequency in Hcy-induced genes. Class 2 and 3 TFs have low and no significant binding frequency, respectively. Class 1 TF binding occurrence in Hcy-induced genes is similar to that in IFN gamma -induced genes, but not that in TNF alpha -induced. We conclude that Hcy is a pro-inflammatory amino acid and induces inflammatory transcriptional signal pathways mediated by class 1 TF. We term class 1 TF as putative Hcy-responsive TFs.
Authors:
Shu Meng; Stephen Ciment; Michael Jan; Tran Tran; Hung Pham; Ramon Cueto; Xiao-Feng Yang; Hong Wang
Related Documents :
2457023 - Albumin and alpha-fetoprotein gene expression in various nonhepatic rat tissues.
1634113 - Sodium butyrate selectively induces transcription of promoters adjacent to the momsv vi...
21669813 - Exploiting genomic resources in studies of speciation and adaptive radiation of lizards...
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2013-01-01
Journal Detail:
Title:  Frontiers in bioscience (Landmark edition)     Volume:  18     ISSN:  1093-4715     ISO Abbreviation:  Front Biosci (Landmark Ed)     Publication Date:  2013  
Date Detail:
Created Date:  2013-01-01     Completed Date:  2013-06-12     Revised Date:  2014-04-15    
Medline Journal Info:
Nlm Unique ID:  101612996     Medline TA:  Front Biosci (Landmark Ed)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  685-95     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Cell Differentiation / drug effects
Cytokines / biosynthesis,  pharmacology*
Gene Expression Regulation / drug effects
Homocysteine / pharmacology*
Humans
Hyperhomocysteinemia / metabolism
Interferon-gamma / pharmacology
Interleukin-10 / pharmacology
Monocytes / cytology,  drug effects,  metabolism*
Promoter Regions, Genetic / physiology
Signal Transduction / drug effects*
Transcription Factors / metabolism*
Grant Support
ID/Acronym/Agency:
HL108910/HL/NHLBI NIH HHS; HL11076/HL/NHLBI NIH HHS; HL67033/HL/NHLBI NIH HHS; HL77288/HL/NHLBI NIH HHS; HL82774/HL/NHLBI NIH HHS; HL94451/HL/NHLBI NIH HHS; R01 HL077288/HL/NHLBI NIH HHS; R01 HL094451/HL/NHLBI NIH HHS; R01 HL108910/HL/NHLBI NIH HHS; R01 HL110764/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Cytokines; 0/Transcription Factors; 0LVT1QZ0BA/Homocysteine; 130068-27-8/Interleukin-10; 82115-62-6/Interferon-gamma
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Recent therapeutic advances and insights of recurrent glioblastoma multiforme.
Next Document:  Matrix proteins as centralized organizers of negative-sense RNA virions.