Document Detail

Homocysteine in small-for-gestational age and appropriate-for-gestational age preterm neonates from mothers receiving folic acid supplementation.
MedLine Citation:
PMID:  20482301     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Prematurity and small-for-gestational age (SGA) neonates are at risk for postnatal complications. Concentrations of total homocysteine (tHcy) might be related to neonatal outcome. We hypothesized that concentrations of tHcy are not related to growth restriction in neonates from mothers receiving 5 mg/day folic acid. We studied a total of 133 preterm neonates from normotensive mothers; SGA (n=96) and appropriate-for-gestational age (AGA, n=37).
METHODS: Concentrations of tHcy, folate and vitamin B12 were measured in venous umbilical cord plasma.
RESULTS: AGA preterm neonates had higher mean birth weight (BW) compared to SGA preterms (2472 g vs. 2007 g; p<0.001) of comparable mean gestational age (GA) (35.1 vs. 35.7 weeks; p=0.059). Concentrations of tHcy (4.86 vs. 4.95 micromol/L), folate (63.3 vs. 55.7 nmol/L), and vitamin B12 (409 vs. 394 pmol/L) were not significantly different between the groups. GA was a strong positive predictor, BW was a significant negative predictor of cord plasma folate. Vitamin B12 concentration was a significant negative predictor of cord tHcy.
CONCLUSIONS: Concentrations of tHcy did not differ between SGA and AGA preterm neonates born to mothers supplemented with folic acid. This finding argues against a causal role for folate deficiency or increased tHcy in growth restriction.
Thushari S Gomes; Ulrike Lindner; Kamani H Tennekoon; Wimal Karandagoda; Ludwig Gortner; Rima Obeid
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Clinical chemistry and laboratory medicine : CCLM / FESCC     Volume:  48     ISSN:  1434-6621     ISO Abbreviation:  Clin. Chem. Lab. Med.     Publication Date:  2010 Aug 
Date Detail:
Created Date:  2010-08-04     Completed Date:  2010-11-24     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9806306     Medline TA:  Clin Chem Lab Med     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  1157-61     Citation Subset:  IM    
Department of General Pediatrics and Neonatology, University Children's Hospital, Faculty of Medicine, Saarland University, Homburg/Saar, Germany.
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MeSH Terms
Birth Weight
Fetal Blood / chemistry
Fetal Growth Retardation / etiology
Folic Acid / analysis,  therapeutic use*
Folic Acid Deficiency / drug therapy
Gestational Age
Homocysteine / blood*
Infant, Newborn
Infant, Small for Gestational Age / blood*
Predictive Value of Tests
Premature Birth
Vitamin B 12 / analysis
Reg. No./Substance:
454-28-4/Homocysteine; 59-30-3/Folic Acid; 68-19-9/Vitamin B 12

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