Document Detail

Homocysteine, folic acid and B-group vitamins in obstetrics and gynaecology.
MedLine Citation:
PMID:  12648856     Owner:  NLM     Status:  MEDLINE    
The amino acid homocysteine is of considerable medical importance because it is involved in the etiopathogeny of cardiovascular diseases. Hyperhomocysteinemia is a factor in the vascular damage that predisposes thrombogenesis and arteriosclerosis. It has also been related to a range of obstetric and gynecologic complications. Numerous studies have demonstrated the association between increased levels of homocysteine and neural tube defects (NTD) and other congenital defects, spontaneous miscarriages, intrauterine growth retardation (IGR), preeclampsia and intrauterine fetal death. Folic acid and other B-group vitamins (B6 and B12) take part in the metabolism of homocysteine and the preventive administration of these vitamins may reduce some of the complications.
M de la Calle; R Usandizaga; M Sancha; F Magdaleno; A Herranz; E Cabrillo
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  European journal of obstetrics, gynecology, and reproductive biology     Volume:  107     ISSN:  0301-2115     ISO Abbreviation:  Eur. J. Obstet. Gynecol. Reprod. Biol.     Publication Date:  2003 Apr 
Date Detail:
Created Date:  2003-03-21     Completed Date:  2003-11-21     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0375672     Medline TA:  Eur J Obstet Gynecol Reprod Biol     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  125-34     Citation Subset:  IM    
Copyright Information:
Copyright 2002 Elsevier Science Ireland Ltd.
Department of Obstetrics and Gynaecology, Hospital La Paz, Paseo de la Castellana n 261, 28046 Madrid, Spain.
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MeSH Terms
Abortion, Spontaneous
Congenital Abnormalities
Contraceptives, Oral, Hormonal
Fetal Death
Fetal Growth Retardation
Folic Acid*
Neural Tube Defects
Uterine Cervical Dysplasia
Vitamin B Complex*
Reg. No./Substance:
0/Contraceptives, Oral, Hormonal; 12001-76-2/Vitamin B Complex; 454-28-4/Homocysteine; 59-30-3/Folic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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