Document Detail

Homocysteine and carotid intima-media thickness in a german population: lack of clinical relevance.
MedLine Citation:
PMID:  17008631     Owner:  NLM     Status:  MEDLINE    
BACKGROUND AND PURPOSE: Common carotid artery intima-media thickness (CCA IMT) is a predictor of stroke. This study aimed to analyze whether homocysteine (Hcys) metabolism influences CCA IMT. METHODS: We analyzed the association of personal, clinical, and biochemical data (multivariate analysis) and of 9 polymorphisms involved in Hcys metabolism (ANOVA) with CCA IMT in 714 individuals of 187 families. RESULTS: CCA IMT was significantly predicted by age, sex, creatinine levels, lipoprotein(a) levels, pack-years of smoking, the presence of hypertension, and the presence of diabetes mellitus but not by Hcys levels. Homozygosity for the T allele of the polymorphism methylenetetrahydrofolate reductase c.677C>T was significantly associated with higher Hcys levels but not with a higher CCA IMT. CONCLUSIONS: These data do not support the thesis that elevated Hcys levels are causally involved in cerebrovascular disease.
Michael Linnebank; Susanna Moskau; Susan Farmand; Klaus Fliessbach; Heike Kölsch; Monika Bös; Christoph Grothe; Dietmar Becker; Ursula Harbrecht; Christoph Pohl; Ullrich Wüllner; Thomas Klockgether
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't     Date:  2006-09-28
Journal Detail:
Title:  Stroke; a journal of cerebral circulation     Volume:  37     ISSN:  1524-4628     ISO Abbreviation:  Stroke     Publication Date:  2006 Nov 
Date Detail:
Created Date:  2006-10-31     Completed Date:  2006-11-14     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0235266     Medline TA:  Stroke     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2840-2     Citation Subset:  IM    
Department of Neurology, University Hospital Bonn, Bonn, Germany.
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MeSH Terms
Carotid Artery, Common / pathology*
Cerebrovascular Disorders / blood,  genetics,  pathology
Homocysteine / blood,  genetics*
Middle Aged
Polymorphism, Genetic / genetics
Tunica Intima / pathology*
Tunica Media / pathology*
Reg. No./Substance:

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