Document Detail

Homocysteine and cardiovascular disease in renal disease.
MedLine Citation:
PMID:  15012699     Owner:  NLM     Status:  MEDLINE    
Elevated homocysteine (hyperhomocysteinaemia) in renal patients is a major concern for physicians. Although cause and effect between homocysteine and cardiovascular disease (CVD) has not been established in either the general population or renal patients, there is much evidence that this relationship does exist. Purported mechanisms that may explain this effect include increases in endothelial injury, smooth muscle cell proliferation, low-density lipoprotein oxidation and changes in haemostatic balance. Renal patients have a much greater incidence of hyperhomocysteinaemia and this may be explained by decreases in either the renal or extrarenal metabolism of the compound. We conclude that data from long-term placebo-controlled trials are urgently required to determine whether hyperhomocysteinaemia in renal patients is a cause of CVD events and requires therapeutic targeting.
Simon K Austen; Jeff S Coombes; Rob G Fassett
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Nephrology (Carlton, Vic.)     Volume:  8     ISSN:  1320-5358     ISO Abbreviation:  Nephrology (Carlton)     Publication Date:  2003 Dec 
Date Detail:
Created Date:  2004-03-11     Completed Date:  2004-08-17     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9615568     Medline TA:  Nephrology (Carlton)     Country:  Australia    
Other Details:
Languages:  eng     Pagination:  285-95     Citation Subset:  IM    
School of Human Movement Studies, University of Queensland, St Lucia, Queensland, Australia.
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MeSH Terms
Cardiovascular Diseases / complications,  metabolism*
Homocysteine / metabolism*
Hyperhomocysteinemia / complications,  drug therapy,  metabolism*
Kidney Diseases / complications,  metabolism*
Reg. No./Substance:

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