Document Detail


Homocysteine and cardiovascular disease in renal disease.
MedLine Citation:
PMID:  15012699     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Elevated homocysteine (hyperhomocysteinaemia) in renal patients is a major concern for physicians. Although cause and effect between homocysteine and cardiovascular disease (CVD) has not been established in either the general population or renal patients, there is much evidence that this relationship does exist. Purported mechanisms that may explain this effect include increases in endothelial injury, smooth muscle cell proliferation, low-density lipoprotein oxidation and changes in haemostatic balance. Renal patients have a much greater incidence of hyperhomocysteinaemia and this may be explained by decreases in either the renal or extrarenal metabolism of the compound. We conclude that data from long-term placebo-controlled trials are urgently required to determine whether hyperhomocysteinaemia in renal patients is a cause of CVD events and requires therapeutic targeting.
Authors:
Simon K Austen; Jeff S Coombes; Rob G Fassett
Related Documents :
15083939 - Comparative toxicity of citalopram and the newer antidepressants after overdose.
23439779 - Disseminated candidiasis 18 years after renal transplantation.
15978149 - Effects of weight loss after biliopancreatic diversion on metabolism and cardiovascular...
19010149 - Treatment with ezetimibe in kidney transplant recipients with uncontrolled dyslipidemia.
16230879 - Considerations in the treatment of dyslipidemia associated with chronic kidney failure ...
11917059 - Long-term impact of renal transplantation on carotid artery properties and on ventricul...
7522469 - Growth and differentiation of meatal skin grafts in the middle ear of the rat.
15528469 - Hypertension-linked mutation in the adducin alpha-subunit leads to higher ap2-mu2 phosp...
24346809 - The impact of modern treatment principles may have eliminated lithium-induced renal fai...
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Nephrology (Carlton, Vic.)     Volume:  8     ISSN:  1320-5358     ISO Abbreviation:  Nephrology (Carlton)     Publication Date:  2003 Dec 
Date Detail:
Created Date:  2004-03-11     Completed Date:  2004-08-17     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9615568     Medline TA:  Nephrology (Carlton)     Country:  Australia    
Other Details:
Languages:  eng     Pagination:  285-95     Citation Subset:  IM    
Affiliation:
School of Human Movement Studies, University of Queensland, St Lucia, Queensland, Australia.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Cardiovascular Diseases / complications,  metabolism*
Homocysteine / metabolism*
Humans
Hyperhomocysteinemia / complications,  drug therapy,  metabolism*
Kidney Diseases / complications,  metabolism*
Chemical
Reg. No./Substance:
454-28-4/Homocysteine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  A mechanism for the development of subepithelial deposits in a patient with type III membranoprolife...
Next Document:  Addition of sertraline to other therapies to reduce dialysis-associated hypotension.