Document Detail


Homocysteine blood level in long-term care residents with oropharyngeal dysphagia: comparison of hand-oral and tube-enteral-fed patients.
MedLine Citation:
PMID:  11871741     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Levels of homocysteine, methylmalonic acid, and relevant vitamins were measured and evaluated in patients with oral dysphagia (OD) receiving long-term care (LTC). METHODS: Group A was composed of 26 orally fed patients, and group B was composed of 25 patients who were fed by nasogastric tube. All patients were hospitalized in the LTC departments of the Geriatric Medical Center, Shmuel Harofe. General and nutritional status were assessed, and levels of vitamins including B12, folate, and B6 were measured along with serum homocysteine and urine methylmalonic acid levels. RESULTS: Homocysteine levels were significantly higher in the orally fed patients (p < .001); 92% had higher-than-normal homocysteine levels. The levels of vitamins B12, folate, and B6 were significantly lower in the orally fed patients (p < .001), although in most patients levels were in the normal range. Notably, the levels of homocysteine were significantly correlated with the levels of all vitamins but not with the albumin or hemoglobin values. Levels of methylmalonic acid were also higher in the orally fed patients, but the difference was not statistically significant, and there was no correlation between vitamin level and methylmalonic acid level. CONCLUSIONS: Orally fed patients with OD have substantially higher homocysteine levels and appreciably lower levels of the relevant vitamins than patients with OD who receive tube feeding. Therefore, homocysteine measurement may be the preferred indicator of vitamin intake in orally fed patients with OD.
Authors:
Arthur Leibovitz; Ben-Ami Sela; Beni Habot; Slava Gavendo; Raisa Lansky; Yael Avni; Rephael Segal
Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  JPEN. Journal of parenteral and enteral nutrition     Volume:  26     ISSN:  0148-6071     ISO Abbreviation:  JPEN J Parenter Enteral Nutr     Publication Date:    2002 Mar-Apr
Date Detail:
Created Date:  2002-03-01     Completed Date:  2002-08-23     Revised Date:  2007-02-21    
Medline Journal Info:
Nlm Unique ID:  7804134     Medline TA:  JPEN J Parenter Enteral Nutr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  94-7     Citation Subset:  IM    
Affiliation:
Geriatric Medical Center, Shmuel Harofe Hospital, Beer Yaakov, Israel.
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MeSH Terms
Descriptor/Qualifier:
Aged
Deglutition Disorders / therapy*
Enteral Nutrition / methods*
Folic Acid / blood
Homocysteine / blood*
Humans
Intubation, Gastrointestinal
Long-Term Care*
Methylmalonic Acid / urine
Nutritional Status*
Oropharynx*
Vitamin B 12 / blood
Vitamin B 6 / blood
Vitamins / administration & dosage
Chemical
Reg. No./Substance:
0/Vitamins; 454-28-4/Homocysteine; 516-05-2/Methylmalonic Acid; 59-30-3/Folic Acid; 68-19-9/Vitamin B 12; 8059-24-3/Vitamin B 6

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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