Document Detail

Homocysteine as a risk factor for cardiovascular disease.
MedLine Citation:
PMID:  21239303     Owner:  NLM     Status:  In-Data-Review    
Homocysteine is an amino acid that appears to damage the vascular endothelium and promote thrombosis. The most frequent causes of hyperhomocyst(e)inemia are the inherited defect of the enzyme cystathinonine B-synthase and nutritional deficiency of vitamin B(12) or folate. Hyperhomocyst(e)inemia is associated, perhaps causally, with atherosclerotic vascular disease. Interactions with risk factors such as cigarette smoking, hyperlipidemia, and hypertension are possible, but not yet defined. Dietary supplementation with vitamin B(12), folate, and other substances can reduce homocysteine levels. Such simple measures may reduce the risk of vascular disease in hyperhomocyst(e)inemic subjects.
I M Graham
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Trends in cardiovascular medicine     Volume:  1     ISSN:  1050-1738     ISO Abbreviation:  Trends Cardiovasc. Med.     Publication Date:  1991 Sep 
Date Detail:
Created Date:  2011-01-17     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9108337     Medline TA:  Trends Cardiovasc Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  244-9     Citation Subset:  -    
Copyright Information:
Copyright © 1991. Published by Elsevier Inc.
Department of Cardiology, Adelaide Hospital, Dublin, Ireland.
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