Document Detail

Homocysteine and abdominal aortic aneurysms.
MedLine Citation:
PMID:  17497968     Owner:  NLM     Status:  MEDLINE    
There is evidence to suggest that increased levels of homocysteine play a significant role in vascular disease. It has been suggested that lowering homocysteine levels by dietary folate supplementation may reduce the risk of stroke and coronary heart disease. It is plausible that homocysteine may also play a role in the pathogenesis of abdominal aortic aneurysms (AAA) and that patients with this disease may benefit from folate supplementation. Our objective was to review the published work with regard to the role of homocysteine in the pathogenesis of AAA. Searches were carried out in published work in English with the keywords 'abdominal aortic aneurysm' and 'homocysteine'. There is evidence from in vitro and animal model studies that activation of metalloproteinases by homocysteine can influence aortic wall structure. Several case-control studies report an association between increased levels of homocysteine and the presence of an AAA. There are conflicting genotypic data concerning the association between methylenetetrahydrofolate reductase gene variants and AAA. Although there is evidence for an association between homocysteine and AAA, it is not strong enough to conclude that it plays a causal role in the pathogenesis of AAA. Further research is needed, given the potential benefit that simple vitamin supplementation may have for patients with AAA.
Paul Moroz; Max T Q Le; Paul E Norman
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  ANZ journal of surgery     Volume:  77     ISSN:  1445-1433     ISO Abbreviation:  ANZ J Surg     Publication Date:  2007 May 
Date Detail:
Created Date:  2007-05-14     Completed Date:  2007-07-24     Revised Date:  2007-12-03    
Medline Journal Info:
Nlm Unique ID:  101086634     Medline TA:  ANZ J Surg     Country:  Australia    
Other Details:
Languages:  eng     Pagination:  329-32     Citation Subset:  IM    
School of Surgery and Pathology, University of Western Australia, Fremantle Hospital, Perth, Western Australia, Australia.
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MeSH Terms
Aortic Aneurysm, Abdominal / etiology*
Enzyme Activation
Homocysteine / physiology*
Metalloproteases / metabolism
Methylenetetrahydrofolate Reductase (NADPH2) / metabolism
Grant Support
R01 HL080010-01/HL/NHLBI NIH HHS
Reg. No./Substance:
454-28-4/Homocysteine; EC Reductase (NADPH2); EC 3.4.-/Metalloproteases

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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