Document Detail

Homocysteine is Related to Aortic Mineralization in Patients with Ischemic Heart Disease.
MedLine Citation:
PMID:  22240908     Owner:  NLM     Status:  Publisher    
Homocysteine is implicated as an early atherosclerotic promoter, which enhances the smooth muscle cell proliferation and produces free radicals that induce cellular damage. These factors must have a role in the progression of atherosclerosis that subsequently leads to vascular mineralization.Aim: Identify a correlation between the plasma concentration of total homocysteine and the amount of minerals that accumulate in the aorta of patients with atherosclerosis.Methods: We performed a cross-sectional study in 13 patients with three-vessel coronary artery disease, undergoing coronary artery bypass surgery. Aortic and mammary artery specimens were analyzed using a scanning electron microscope with an energy dispersive X-ray spectrometer. The homocysteine was determined using an immunonephelometry method.Results: The amount of minerals in the aorta was greater (300±181.6 particles per 500 µm(2)) than that in the mammary artery (64±45 particles per 500 µm(2))(p < 0.01). The average tHcy was 9.5±2.3 µmol/L. The Spearman's rank correlation coefficient was positive between tHcy, and aortic iron (p < 0.05).Conclusions: Our study demonstrates that the aorta is dramatically affected by mineralization compared to the mammary artery. In addition, a direct correlation was identified between the levels of tHcy and the iron particles in the aortic wall.
Marco A Peña-Duque; Manuel A Baños-González; Benjamín Valente-Acosta; Luis Gerardo Rodríguez-Lobato; Marco A Martínez-Ríos; Guillermo Cardoso-Saldaña; Rodolfo Barragán-García; Valentín Herrera-Alarcón; Carlos Linares-López; Hugo Delgado-Granados; Aurora de la Peña-Díaz1 2
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-1-12
Journal Detail:
Title:  Journal of atherosclerosis and thrombosis     Volume:  -     ISSN:  1880-3873     ISO Abbreviation:  -     Publication Date:  2012 Jan 
Date Detail:
Created Date:  2012-1-13     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9506298     Medline TA:  J Atheroscler Thromb     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Instituto Nacional de Cardiología "Ignacio Chávez", Grupo Genética Intervencionista, Departamentos de Biología Molecular, Hemodinámica, Endocrinología.
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