| Homocysteine is Related to Aortic Mineralization in Patients with Ischemic Heart Disease. | |
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MedLine Citation:
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PMID: 22240908 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Homocysteine is implicated as an early atherosclerotic promoter, which enhances the smooth muscle cell proliferation and produces free radicals that induce cellular damage. These factors must have a role in the progression of atherosclerosis that subsequently leads to vascular mineralization.Aim: Identify a correlation between the plasma concentration of total homocysteine and the amount of minerals that accumulate in the aorta of patients with atherosclerosis.Methods: We performed a cross-sectional study in 13 patients with three-vessel coronary artery disease, undergoing coronary artery bypass surgery. Aortic and mammary artery specimens were analyzed using a scanning electron microscope with an energy dispersive X-ray spectrometer. The homocysteine was determined using an immunonephelometry method.Results: The amount of minerals in the aorta was greater (300±181.6 particles per 500 µm(2)) than that in the mammary artery (64±45 particles per 500 µm(2))(p < 0.01). The average tHcy was 9.5±2.3 µmol/L. The Spearman's rank correlation coefficient was positive between tHcy, and aortic iron (p < 0.05).Conclusions: Our study demonstrates that the aorta is dramatically affected by mineralization compared to the mammary artery. In addition, a direct correlation was identified between the levels of tHcy and the iron particles in the aortic wall. |
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Authors:
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Marco A Peña-Duque; Manuel A Baños-González; Benjamín Valente-Acosta; Luis Gerardo Rodríguez-Lobato; Marco A Martínez-Ríos; Guillermo Cardoso-Saldaña; Rodolfo Barragán-García; Valentín Herrera-Alarcón; Carlos Linares-López; Hugo Delgado-Granados; Aurora de la Peña-Díaz1 2 |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-1-12 |
Journal Detail:
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Title: Journal of atherosclerosis and thrombosis Volume: - ISSN: 1880-3873 ISO Abbreviation: - Publication Date: 2012 Jan |
Date Detail:
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Created Date: 2012-1-13 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9506298 Medline TA: J Atheroscler Thromb Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Instituto Nacional de Cardiología "Ignacio Chávez", Grupo Genética Intervencionista, Departamentos de Biología Molecular, Hemodinámica, Endocrinología. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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