| Homocysteine and Hypertension in Diabetes: Does PPARgamma Have a Regulatory Role? | |
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MedLine Citation:
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PMID: 20613990 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Dysfunction of macro- and microvessels is a major cause of morbidity and mortality in patients with cardio-renovascular diseases such as atherosclerosis, hypertension, and diabetes. Renal failure and impairment of renal function due to vasoconstriction of the glomerular arteriole in diabetic nephropathy leads to renal volume retention and increase in plasma homocysteine level. Homocysteine, which is a nonprotein amino acid, at elevated levels is an independent cardio-renovascular risk factor. Homocysteine induces oxidative injury of vascular endothelial cells, involved in matrix remodeling through modulation of the matrix metalloproteinase (MMP)/tissue inhibitor of metalloproteinase (TIMP) axis, and increased formation and accumulation of extracellular matrix protein, such as collagen. In heart this leads to increased endothelial-myocyte uncoupling resulting in diastolic dysfunction and hypertension. In the kidney, increased matrix accumulation in the glomerulus causes glomerulosclerosis resulting in hypofiltration, increased renal volume retention, and hypertension. PPARgamma agonist reduces tissue homocysteine levels and is reported to ameliorate homocysteine-induced deleterious vascular effects in diabetes. This review, in light of current information, focuses on the beneficial effects of PPARgamma agonist in homocysteine-associated hypertension and vascular remodeling in diabetes. |
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Authors:
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Utpal Sen; Suresh C Tyagi |
Publication Detail:
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Type: Journal Article Date: 2010-06-29 |
Journal Detail:
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Title: PPAR research Volume: 2010 ISSN: 1687-4765 ISO Abbreviation: PPAR Res Publication Date: 2010 |
Date Detail:
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Created Date: 2010-07-08 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101269101 Medline TA: PPAR Res Country: United States |
Other Details:
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Languages: eng Pagination: 806538 Citation Subset: - |
Affiliation:
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Department of Physiology and Biophysics, University of Louisville School of Medicine, 500 South Preston Street, Louisville, KY 40202, USA. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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