Document Detail


Homocysteine, cardiovascular inflammation, and myocardial remodeling.
MedLine Citation:
PMID:  20932268     Owner:  NLM     Status:  In-Process    
Abstract/OtherAbstract:
Chronic heart failure is a major public health problem causing considerable morbidity and mortality. Recent studies have shown that an elevated plasma level of homocysteine is a strong independent risk factor for heart failure, in addition to atherosclerotic disease. Preclinical studies have demonstrated that induced hyperhomocysteinemia acts via multiple pathogenic mechanisms, including inflammation and oxidative stress, to promote adverse cardiac remodeling and failure. However, clinical studies have not conclusively shown a causative relation between hyperhomocysteinemia and cardiovascular disease. This article will review current data concerning homocysteine and its pathogenic relationship to heart failure.
Authors:
Jennifer M Finch; Jacob Joseph
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Cardiovascular & hematological disorders drug targets     Volume:  10     ISSN:  1871-529X     ISO Abbreviation:  Cardiovasc Hematol Disord Drug Targets     Publication Date:  2010 Dec 
Date Detail:
Created Date:  2011-01-10     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101269160     Medline TA:  Cardiovasc Hematol Disord Drug Targets     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  241-5     Citation Subset:  IM    
Affiliation:
Department of Medicine, Boston University School of Medicine, Massachusetts, USA.
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