Document Detail


Homer: a protein that selectively binds metabotropic glutamate receptors.
MedLine Citation:
PMID:  9069287     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Spatial localization and clustering of membrane proteins is critical to neuronal development and synaptic plasticity. Recent studies have identified a family of proteins, the PDZ proteins, that contain modular PDZ domains and interact with synaptic ionotropic glutamate receptors and ion channels. PDZ proteins are thought to have a role in defining the cellular distribution of the proteins that interact with them. Here we report a novel dendritic protein, Homer, that contains a single, PDZ-like domain and binds specifically to the carboxy terminus of phosphoinositide-linked metabotropic glutamate receptors. Homer is highly divergent from known PDZ proteins and seems to represent a novel family. The Homer gene is also distinct from members of the PDZ family in that its expression is regulated as an immediate early gene and is dynamically responsive to physiological synaptic activity, particularly during cortical development. This dynamic transcriptional control suggests that Homer mediates a novel cellular mechanism that regulates metabotropic glutamate signalling.
Authors:
P R Brakeman; A A Lanahan; R O'Brien; K Roche; C A Barnes; R L Huganir; P F Worley
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Nature     Volume:  386     ISSN:  0028-0836     ISO Abbreviation:  Nature     Publication Date:  1997 Mar 
Date Detail:
Created Date:  1997-04-07     Completed Date:  1997-04-07     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0410462     Medline TA:  Nature     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  284-8     Citation Subset:  IM    
Affiliation:
Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA.
Data Bank Information
Bank Name/Acc. No.:
GENBANK/U92079
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MeSH Terms
Descriptor/Qualifier:
Animals
Binding Sites
Brain / metabolism
Carrier Proteins / chemistry,  genetics,  metabolism*
Cell Line
Cloning, Molecular
Gene Expression Regulation
Hippocampus / metabolism
Humans
Immunoenzyme Techniques
Mice
Molecular Sequence Data
Nerve Tissue Proteins / chemistry,  genetics,  metabolism*
Neurons / metabolism
Neuropeptides / chemistry,  genetics,  metabolism*
RNA, Messenger / metabolism
Rats
Receptors, Metabotropic Glutamate / metabolism*
Sequence Deletion
Sequence Homology, Amino Acid
Signal Transduction
Synapses / metabolism*
Chemical
Reg. No./Substance:
0/Carrier Proteins; 0/Homer protein; 0/Nerve Tissue Proteins; 0/Neuropeptides; 0/RNA, Messenger; 0/Receptors, Metabotropic Glutamate
Comments/Corrections
Comment In:
Nature. 1997 Mar 20;386(6622):221, 223   [PMID:  9069275 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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