Document Detail

Homeotic duplication of the pelvic body segment in regenerating tadpole tails induced by retinoic acid.
MedLine Citation:
PMID:  24173593     Owner:  NLM     Status:  In-Data-Review    
Homeosis, the ectopic formation of a body part, is one of the key phenomena that prompted the identification of the essential selector genes controlling body organization. Shared elements of such homeotic genes exist in all studied animal classes, but homeotic transformations of the same order of magnitude as in insects, such as the duplication of the thorax in Drosophila mutants, have not been described in vertebrates. Here we investigate the capacity of retinoic acid to modify tail regeneration in amphibians. We show that retinoic acid causes the formation of an additional body segment in regenerating tails of Rana temporaria tadpoles. A second pelvic section, including vertebral elements, pelvic girdle elements and limb buds, forms at the mid-tail level. This is the first report of a homeotic duplication of a whole body segment in vertebrate axial regeneration.
G B Müller; J Streicher; R J Müller
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Development genes and evolution     Volume:  206     ISSN:  0949-944X     ISO Abbreviation:  Dev. Genes Evol.     Publication Date:  1996 Dec 
Date Detail:
Created Date:  2013-10-31     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9613264     Medline TA:  Dev Genes Evol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  344-8     Citation Subset:  -    
Department of Anatomy, University of Vienna, Währingerstraße 13, A-1090 Wien, Austria, , , , , , AT.
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