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Homeotic Gene Regulation: A Paradigm for Epigenetic Mechanisms Underlying Organismal Development.
MedLine Citation:
PMID:  23150252     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
The organization of eukaryotic genome into chromatin within the nucleus eventually dictates the cell type specific expression pattern of genes. This higher order of chromatin organization is established during development and dynamically maintained throughout the life span. Developmental mechanisms are conserved in bilaterians and hence they have body plan in common, which is achieved by regulatory networks controlling cell type specific gene expression. Homeotic genes are conserved in metazoans and are crucial for animal development as they specify cell type identity along the anterior-posterior body axis. Hox genes are the best studied in the context of epigenetic regulation that has led to significant understanding of the organismal development. Epigenome specific regulation is brought about by conserved chromatin modulating factors like PcG/trxG proteins during development and differentiation. Here we discuss the conserved epigenetic mechanisms relevant to homeotic gene regulation in metazoans.
Authors:
Navneet K Matharu; Vasanthi Dasari; Rakesh K Mishra
Publication Detail:
Type:  JOURNAL ARTICLE    
Journal Detail:
Title:  Sub-cellular biochemistry     Volume:  61     ISSN:  0306-0225     ISO Abbreviation:  Subcell. Biochem.     Publication Date:  2013  
Date Detail:
Created Date:  2012-11-14     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0316571     Medline TA:  Subcell Biochem     Country:  -    
Other Details:
Languages:  ENG     Pagination:  177-207     Citation Subset:  -    
Affiliation:
Centre for Cellular and Molecular Biology, Council of Scientific and Industrial Research (CSIR), Uppal Road, Hyderabad, 500 007, India.
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