| Homeostatic model assessment and risk for hypertension during pregnancy: a longitudinal prospective study. | |
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MedLine Citation:
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PMID: 15580541 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The purpose of this study was to determine the association between insulin resistance and hypertension during pregnancy with the homeostatic model assessment (HOMA-IR). A longitudinal prospective study was carried out. One hundred sixty normotensive pregnant women were followed from the first trimester until delivery. HOMA-IR levels were determined each trimester. Statistical analysis included one-way analysis of variance and multivariate logistic regression. At follow-up, 134 women (83.8%) remained normotensive, 18 (11.2%) developed gestational hypertension, and 8 (5%) developed preeclampsia. At first trimester, HOMA-IR levels were higher in women who developed gestational hypertension (2.1 +/- 0.2) than in women who developed preeclampsia (1.2 +/- 0.0), or remained normotensive (1.2 +/- 0.3); p < 0.01. In the logistic regression analysis, HOMA-IR levels at first trimester were statistically significant ( p = 0.03) to predict development of gestational hypertension. Our results support the use of the HOMA-IR as an alternative index for the assessment of the risk for hypertension during pregnancy. |
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Authors:
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Gustavo Romero-Gutiérrez; Juan Manuel Malacara; Norma Amador; César Fierro-Martínez; Luis Manuel Muñoz-Guevara; Roberto Molina-Rodríguez |
Publication Detail:
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Type: Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: American journal of perinatology Volume: 21 ISSN: 0735-1631 ISO Abbreviation: Am J Perinatol Publication Date: 2004 Nov |
Date Detail:
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Created Date: 2004-12-06 Completed Date: 2005-03-03 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8405212 Medline TA: Am J Perinatol Country: United States |
Other Details:
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Languages: eng Pagination: 455-62 Citation Subset: IM |
Affiliation:
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Unit of Clinical Epidemiological Research, Department of Obstetrics and Gynecology, Mexican Institute of Social Security, Leon, Mexico. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Decision Support Techniques* Female Homeostasis Humans Insulin Resistance* Longitudinal Studies Mexico Pre-Eclampsia / diagnosis*, etiology*, pathology Predictive Value of Tests Pregnancy Pregnancy Trimesters Prospective Studies Risk Factors Severity of Illness Index |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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