Document Detail

Homeostatic model assessment and risk for hypertension during pregnancy: a longitudinal prospective study.
MedLine Citation:
PMID:  15580541     Owner:  NLM     Status:  MEDLINE    
The purpose of this study was to determine the association between insulin resistance and hypertension during pregnancy with the homeostatic model assessment (HOMA-IR). A longitudinal prospective study was carried out. One hundred sixty normotensive pregnant women were followed from the first trimester until delivery. HOMA-IR levels were determined each trimester. Statistical analysis included one-way analysis of variance and multivariate logistic regression. At follow-up, 134 women (83.8%) remained normotensive, 18 (11.2%) developed gestational hypertension, and 8 (5%) developed preeclampsia. At first trimester, HOMA-IR levels were higher in women who developed gestational hypertension (2.1 +/- 0.2) than in women who developed preeclampsia (1.2 +/- 0.0), or remained normotensive (1.2 +/- 0.3); p < 0.01. In the logistic regression analysis, HOMA-IR levels at first trimester were statistically significant ( p = 0.03) to predict development of gestational hypertension. Our results support the use of the HOMA-IR as an alternative index for the assessment of the risk for hypertension during pregnancy.
Gustavo Romero-Gutiérrez; Juan Manuel Malacara; Norma Amador; César Fierro-Martínez; Luis Manuel Muñoz-Guevara; Roberto Molina-Rodríguez
Publication Detail:
Type:  Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  American journal of perinatology     Volume:  21     ISSN:  0735-1631     ISO Abbreviation:  Am J Perinatol     Publication Date:  2004 Nov 
Date Detail:
Created Date:  2004-12-06     Completed Date:  2005-03-03     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8405212     Medline TA:  Am J Perinatol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  455-62     Citation Subset:  IM    
Unit of Clinical Epidemiological Research, Department of Obstetrics and Gynecology, Mexican Institute of Social Security, Leon, Mexico.
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MeSH Terms
Decision Support Techniques*
Insulin Resistance*
Longitudinal Studies
Pre-Eclampsia / diagnosis*,  etiology*,  pathology
Predictive Value of Tests
Pregnancy Trimesters
Prospective Studies
Risk Factors
Severity of Illness Index

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