Document Detail


Homeostasis of exercise hyperpnea and optimal sensorimotor integration: the internal model paradigm.
MedLine Citation:
PMID:  17416554     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Homeostasis is a basic tenet of biomedicine and an open problem for many physiological control systems. Among them, none has been more extensively studied and intensely debated than the dilemma of exercise hyperpnea - a paradoxical homeostatic increase of respiratory ventilation that is geared to metabolic demands instead of the normal chemoreflex mechanism. Classical control theory has led to a plethora of "feedback/feedforward control" or "set point" hypotheses for homeostatic regulation, yet so far none of them has proved satisfactory in explaining exercise hyperpnea and its interactions with other respiratory inputs. Instead, the available evidence points to a far more sophisticated respiratory controller capable of integrating multiple afferent and efferent signals in adapting the ventilatory pattern toward optimality relative to conflicting homeostatic, energetic and other objectives. This optimality principle parsimoniously mimics exercise hyperpnea, chemoreflex and a host of characteristic respiratory responses to abnormal gas exchange or mechanical loading/unloading in health and in cardiopulmonary diseases - all without resorting to a feedforward "exercise stimulus". Rather, an emergent controller signal encoding the projected metabolic level is predicted by the principle as an exercise-induced 'mental percept' or 'internal model', presumably engendered by associative learning (operant conditioning or classical conditioning) which achieves optimality through continuous identification of, and adaptation to, the causal relationship between respiratory motor output and resultant chemical-mechanical afferent feedbacks. This internal model self-tuning adaptive control paradigm opens a new challenge and exciting opportunity for experimental and theoretical elucidations of the mechanisms of respiratory control - and of homeostatic regulation and sensorimotor integration in general.
Authors:
Chi-Sang Poon; Chung Tin; Yunguo Yu
Related Documents :
12486024 - Neuroplasticity in respiratory motor control.
6422704 - Seizure duration in unilateral electroconvulsive therapy. the effect of hypocapnia indu...
6833054 - Coupling of ventilation to pulmonary gas exchange during nonsteady-state work in men.
852474 - Profound reflex bradycardia produced by transient hypoxia or hypercapnia in man.
18195174 - Apoptosis signal-regulating kinase 1/p38 signaling pathway negatively regulates physiol...
15122684 - Assessment of human pulmonary function using oxygen-enhanced t(1) imaging in patients w...
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review     Date:  2007-03-07
Journal Detail:
Title:  Respiratory physiology & neurobiology     Volume:  159     ISSN:  1569-9048     ISO Abbreviation:  Respir Physiol Neurobiol     Publication Date:  2007 Oct 
Date Detail:
Created Date:  2007-10-01     Completed Date:  2007-12-12     Revised Date:  2014-09-14    
Medline Journal Info:
Nlm Unique ID:  101140022     Medline TA:  Respir Physiol Neurobiol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  1-13; discussion 14-20     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adaptation, Physiological*
Animals
Carbon Dioxide / blood
Chemoreceptor Cells / physiology
Exercise / physiology*
Homeostasis / physiology*
Humans
Oxygen / blood
Respiratory Physiological Phenomena*
Grant Support
ID/Acronym/Agency:
EB005460/EB/NIBIB NIH HHS; HL 079503/HL/NHLBI NIH HHS; HL067966/HL/NHLBI NIH HHS; HL072849/HL/NHLBI NIH HHS; HL075014/HL/NHLBI NIH HHS; R01 HL067966/HL/NHLBI NIH HHS; R01 HL067966-04/HL/NHLBI NIH HHS; R01 HL072849/HL/NHLBI NIH HHS; R01 HL072849-03/HL/NHLBI NIH HHS; R01 HL079503/HL/NHLBI NIH HHS; R01 HL079503-02/HL/NHLBI NIH HHS; R21 EB005460/EB/NIBIB NIH HHS; R21 EB005460-02/EB/NIBIB NIH HHS; R21 HL075014/HL/NHLBI NIH HHS; R21 HL075014-02/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
142M471B3J/Carbon Dioxide; S88TT14065/Oxygen
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Ex vivo gene therapy cures a blistering skin disease.
Next Document:  Determination and pharmacokinetics of orientin in rabbit plasma by liquid chromatography after intra...