Document Detail

Homeostasis and Gauss statistics: barriers to understanding natural variability.
MedLine Citation:
PMID:  20604819     Owner:  NLM     Status:  MEDLINE    
RATIONALE: In this paper, the concept of knowledge is argued to be the top of a three-tiered system of science.
AIMS AND OBJECTIVES: The first tier is that of measurement and data, followed by information consisting of the patterns within the data, and ending with theory that interprets the patterns and yields knowledge. Thus, when a scientific theory ceases to be consistent with the database the knowledge based on that theory must be re-examined and potentially modified.
RESULTS: Consequently, all knowledge, like glory, is transient.
METHODS: Herein we focus on the non-normal statistics of physiologic time series and conclude that the empirical inverse power-law statistics and long-time correlations are inconsistent with the theoretical notion of homeostasis.
CONCLUSIONS: We suggest replacing the notion of homeostasis with that of Fractal Physiology.
Bruce J West
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of evaluation in clinical practice     Volume:  16     ISSN:  1365-2753     ISO Abbreviation:  J Eval Clin Pract     Publication Date:  2010 Jun 
Date Detail:
Created Date:  2010-07-07     Completed Date:  2010-11-22     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9609066     Medline TA:  J Eval Clin Pract     Country:  England    
Other Details:
Languages:  eng     Pagination:  403-8     Citation Subset:  IM    
US Army Research Office, Research Triangle Park, Durham, NC 27709, USA.
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MeSH Terms
Evidence-Based Medicine
Models, Theoretical*
Normal Distribution

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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