Document Detail

Homeobox transcription factor Pitx2: The rise of an asymmetry gene in cardiogenesis and arrhythmogenesis.
MedLine Citation:
PMID:  23953978     Owner:  NLM     Status:  Publisher    
The homeobox transcription factor Pitx2 displays a highly specific expression pattern during embryogenesis. Gain and loss of function experiments have unraveled its pivotal role in left-right signaling. Conditional deletion in mice has demonstrated a complex and intricate role for Pitx2 in distinct aspects of cardiac development and more recently a link to atrial fibrillation has been proposed based on genome-wide association studies. In this review we will revise the role of Pitx2 in the developing heart, starting from the early events of left-right determination followed by its role in cardiac morphogenesis and ending with its role in cardiac arrhythmogenesis.
Diego Franco; Vincent M Christoffels; Marina Campione
Related Documents :
23868858 - Prospective randomized study to assess the efficacy of site and rate of atrial pacing o...
24000158 - Fetal intelligent navigation echocardiography (fine): a novel method for rapid, simple,...
24062938 - Heart failure due to 'stress cardiomyopathy': a severe manifestation of the opioid with...
17584568 - Does coronary angioplasty after timely thrombolysis improve microvascular perfusion and...
23333438 - Mirna expression in pediatric failing human heart.
17122428 - The real estate factor: quantifying the impact of infarct location on stroke severity.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-8-14
Journal Detail:
Title:  Trends in cardiovascular medicine     Volume:  -     ISSN:  1873-2615     ISO Abbreviation:  Trends Cardiovasc. Med.     Publication Date:  2013 Aug 
Date Detail:
Created Date:  2013-8-19     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9108337     Medline TA:  Trends Cardiovasc Med     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2013 Elsevier Inc. All rights reserved.
Department of Experimental Biology B3-362, University of Jaén, Jaen 23071, Spain. Electronic address:
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Modeling myocardial growth and hypertrophy in engineered heart muscle.
Next Document:  Genomic instability and vascular aging: A focus on nucleotide excision repair.