Document Detail


Home sweet home: skin stem cell niches.
MedLine Citation:
PMID:  22410738     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The epidermis and its appendages, such as the hair follicle (HF), continually regenerate throughout postnatal mammalian life due to the activity of resident epithelial stem cells (SCs). The follicular SC niche, or the bulge, is composed of a heterogeneous population of self-renewing multipotent cells. Multiple intrinsic molecular mechanisms promote the transition of follicular SCs from quiescence to activation. In addition, numerous extrinsic cell types influence the activity and characteristics of bulge cells. Ultimately, the balance between these intrinsic and extrinsic mechanisms influences the function of bulge cells during homeostasis and tissue regeneration and likely contributes to skin tumorigenesis. Here, we review both the intrinsic and extrinsic factors that contribute to the skin SC niche.
Authors:
Jill Goldstein; Valerie Horsley
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review     Date:  2012-03-13
Journal Detail:
Title:  Cellular and molecular life sciences : CMLS     Volume:  69     ISSN:  1420-9071     ISO Abbreviation:  Cell. Mol. Life Sci.     Publication Date:  2012 Aug 
Date Detail:
Created Date:  2012-07-13     Completed Date:  2012-09-26     Revised Date:  2013-08-14    
Medline Journal Info:
Nlm Unique ID:  9705402     Medline TA:  Cell Mol Life Sci     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  2573-82     Citation Subset:  IM    
Affiliation:
Department of Molecular, Cell and Developmental Biology, Yale University, New Haven, CT 06520, USA.
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MeSH Terms
Descriptor/Qualifier:
Adipocytes / cytology,  physiology
Animals
Gene Expression Profiling
Hair Follicle / cytology
Humans
Melanocytes / cytology,  physiology
Models, Biological
Multipotent Stem Cells / cytology*,  physiology
Muscle Cells / cytology,  physiology
Neurons / cytology,  physiology
Signal Transduction
Skin / cytology*,  innervation
Skin Neoplasms / etiology
Skin Physiological Phenomena
Stem Cell Niche / genetics,  physiology*
Grant Support
ID/Acronym/Agency:
AR054775/AR/NIAMS NIH HHS; AR060295/AR/NIAMS NIH HHS; R00 AR054775/AR/NIAMS NIH HHS; R01 AR060295/AR/NIAMS NIH HHS
Comments/Corrections

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