| Home sweet home: skin stem cell niches. | |
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MedLine Citation:
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PMID: 22410738 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The epidermis and its appendages, such as the hair follicle (HF), continually regenerate throughout postnatal mammalian life due to the activity of resident epithelial stem cells (SCs). The follicular SC niche, or the bulge, is composed of a heterogeneous population of self-renewing multipotent cells. Multiple intrinsic molecular mechanisms promote the transition of follicular SCs from quiescence to activation. In addition, numerous extrinsic cell types influence the activity and characteristics of bulge cells. Ultimately, the balance between these intrinsic and extrinsic mechanisms influences the function of bulge cells during homeostasis and tissue regeneration and likely contributes to skin tumorigenesis. Here, we review both the intrinsic and extrinsic factors that contribute to the skin SC niche. |
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Authors:
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Jill Goldstein; Valerie Horsley |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review Date: 2012-03-13 |
Journal Detail:
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Title: Cellular and molecular life sciences : CMLS Volume: 69 ISSN: 1420-9071 ISO Abbreviation: Cell. Mol. Life Sci. Publication Date: 2012 Aug |
Date Detail:
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Created Date: 2012-07-13 Completed Date: 2012-09-26 Revised Date: 2013-04-16 |
Medline Journal Info:
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Nlm Unique ID: 9705402 Medline TA: Cell Mol Life Sci Country: Switzerland |
Other Details:
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Languages: eng Pagination: 2573-82 Citation Subset: IM |
Affiliation:
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Department of Molecular, Cell and Developmental Biology, Yale University, New Haven, CT 06520, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adipocytes
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cytology,
physiology Animals Gene Expression Profiling Hair Follicle / cytology Humans Melanocytes / cytology, physiology Models, Biological Multipotent Stem Cells / cytology*, physiology Muscle Cells / cytology, physiology Neurons / cytology, physiology Signal Transduction Skin / cytology*, innervation Skin Neoplasms / etiology Skin Physiological Phenomena Stem Cell Niche / genetics, physiology* |
| Grant Support | |
ID/Acronym/Agency:
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AR054775/AR/NIAMS NIH HHS; AR060295/AR/NIAMS NIH HHS; R00 AR054775/AR/NIAMS NIH HHS; R01 AR060295/AR/NIAMS NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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