Document Detail


Home fortification of complementary foods with micronutrient supplements is well accepted and has positive effects on infant iron status in Ghana.
MedLine Citation:
PMID:  18400716     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Micronutrient deficiencies are common during infancy, and optimal approaches for their prevention need to be identified. OBJECTIVE: The objective was to compare the efficacy and acceptability of Sprinkles (SP), crushable Nutritabs (NT), and fat-based Nutributter (NB; 108 kcal/d), which provide 6, 16, and 19 vitamins and minerals, respectively, when used for home fortification of complementary foods. DESIGN: Ghanaian infants were randomly assigned to receive SP (n = 105), NT (n = 105), or NB (n = 103) daily from 6 to 12 mo of age. We assessed dietary intake, morbidity, and compliance weekly. Hemoglobin and plasma ferritin, TfR, C-reactive protein, and zinc were measured at 6 and 12 mo. We used an exit interview to assess acceptability. A randomly selected control group of infants who received no intervention (NI; n = 96) were assessed at 12 mo. RESULTS: All supplements were well accepted, and the mean percentage of days that supplements were consumed (87%) did not differ between groups. At 12 mo, all 3 intervention groups had significantly higher ferritin and lower TfR concentrations than did the NI control group. Mean (+/- SD) hemoglobin was significantly higher in NT (112 +/- 14 g/L) and NB (114 +/- 14 g/L) but not in SP (110 +/- 14 g/L) infants than in NI infants (106 +/- 14 g/L). The prevalence of iron deficiency anemia was 31% in the NI control group compared with 10% in the intervention groups combined (P < 0.0001). CONCLUSION: All 3 options for home fortification of complementary foods are effective for reducing the prevalence of iron deficiency in such populations.
Authors:
Seth Adu-Afarwuah; Anna Lartey; Kenneth H Brown; Stanley Zlotkin; André Briend; Kathryn G Dewey
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  The American journal of clinical nutrition     Volume:  87     ISSN:  1938-3207     ISO Abbreviation:  Am. J. Clin. Nutr.     Publication Date:  2008 Apr 
Date Detail:
Created Date:  2008-04-10     Completed Date:  2008-04-28     Revised Date:  2009-05-15    
Medline Journal Info:
Nlm Unique ID:  0376027     Medline TA:  Am J Clin Nutr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  929-38     Citation Subset:  AIM; IM    
Affiliation:
Program in International and Community Nutrition, University of California, Davis, CA 95616-8669, USA.
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MeSH Terms
Descriptor/Qualifier:
Anemia, Iron-Deficiency / blood,  epidemiology,  prevention & control*
C-Reactive Protein / metabolism
Female
Ferritins / blood
Food, Fortified*
Ghana / epidemiology
Growth / drug effects
Hemoglobins / metabolism
Humans
Infant
Infant Food
Infant Nutrition Disorders / prevention & control
Infant Nutritional Physiological Phenomena / drug effects,  physiology*
Iron / blood*
Male
Micronutrients / administration & dosage*,  deficiency
Nutritional Status*
Prevalence
Transferrin / metabolism
Weaning
Zinc / blood
Chemical
Reg. No./Substance:
0/Hemoglobins; 0/Micronutrients; 11096-37-0/Transferrin; 7439-89-6/Iron; 7440-66-6/Zinc; 9007-41-4/C-Reactive Protein; 9007-73-2/Ferritins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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