Document Detail


Home bases formed to visual cues but not to self-movement (dead reckoning) cues in exploring hippocampectomized rats.
MedLine Citation:
PMID:  16262675     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Spatial theory proposes that the hippocampus contributes to exploratory behavior allowing animals to acquire information about their environment. In the present study, the exploratory movements of control rats, bulbectomized (anosmic) rats and hippocampectomized rats using the neurotoxin N-methyl-D-aspartate (NMDA) were monitored on a large circular table without walls and around which visual cues were manipulated. The rats displayed organized spatial behavior in that they developed home bases, one or more places operationally defined as those in which they spent a preponderance of time, in which they moved slowly, and to which they returned after excursions. Control rats and hippocampectomized rats were similar in that they established home bases: (i) adjacent to a proximal stable or moving visual landmark; (ii) in relation to more distant visual room cues; and (iii) in relation to contextually conditioned visual cues. Nevertheless, in exploratory tests given under infrared light, a wavelength to which rats are insensitive, control rats and bulbectomized rats established one or more home bases that were not dependent upon surface (e.g. olfactory) cues, whereas home base behavior was absent/fragmented in hippocampectomized rats. Thus, exploratory behavior, as exemplified by home base behavior, is organized in control and hippocampectomized rats in relation to visual cues, but is not organized in hippocampectomized rats when visual cues are absent. This result is discussed in relation to the idea that the hippocampus contributes to spatial behavior that is dependent upon guidance (dead reckoning) derived from self-movement cues.
Authors:
Dustin J Hines; Ian Q Whishaw
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The European journal of neuroscience     Volume:  22     ISSN:  0953-816X     ISO Abbreviation:  Eur. J. Neurosci.     Publication Date:  2005 Nov 
Date Detail:
Created Date:  2005-11-02     Completed Date:  2006-01-17     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8918110     Medline TA:  Eur J Neurosci     Country:  France    
Other Details:
Languages:  eng     Pagination:  2363-75     Citation Subset:  IM    
Affiliation:
Canadian Centre for Behavioural Neuroscience, Department of Psychology and Neuroscience, University of Lethbridge, Lethbridge, Alberta, Canada T1K 3M4.
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MeSH Terms
Descriptor/Qualifier:
Analysis of Variance
Animals
Behavior, Animal
Brain Injuries / chemically induced,  physiopathology*
Cues*
Exploratory Behavior / physiology*
Female
Hippocampus / physiopathology*
Motor Activity / physiology
Movement / physiology
N-Methylaspartate
Photic Stimulation / methods
Rats
Rats, Long-Evans
Reaction Time / physiology
Space Perception / physiology*
Spatial Behavior / physiology*
Time Factors
Video Recording / methods
Chemical
Reg. No./Substance:
6384-92-5/N-Methylaspartate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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