Document Detail


Home intervention improves cognitive and social-emotional scores in iron-deficient anemic infants.
MedLine Citation:
PMID:  20855384     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Iron-deficiency anemia (IDA) is associated with alterations in infant behavior and development that may not be corrected with iron therapy.
OBJECTIVE: To determine if a home-based intervention to foster child development improves behavior and development of infants with IDA.
METHODS: Infants with IDA and nonanemic infants aged 6 and 12 months were treated with oral iron and randomly assigned to a year of surveillance or intervention. Infants in the surveillance group were visited weekly, and information on iron intake, feeding, and health were recorded. Infants in the intervention were visited weekly, and the home visits included an hour-long program to foster child development by providing support to the mother-infant relationship. The number of infants enrolled was 128 (66 who received intervention) and 149 (70 intervention) at 6 and 12 months, respectively. Psychologists who were unaware of iron status and intervention assignment assessed infants' cognitive, motor, and social-emotional development (Bayley Scales) at the beginning, midpoint, and end of the year; 116 6-month-olds and 134 12-month-olds had at least 2 assessments. Hierarchical linear modeling was used to analyze change over time.
RESULTS: Infants with IDA, regardless of enrollment age, were rated as less positive in social-emotional behavior at baseline. There were significant interactions between iron status and intervention associated with change in cognitive performance and positive social-emotional behavior. Infants with IDA who received intervention had developmental trajectories comparable to those of nonanemic infants in the intervention and surveillance groups, but these infants did not catch up in social-emotional behavior. Infants with IDA who received surveillance showed less increase in cognitive scores and had declines in positive social-emotional ratings.
CONCLUSIONS: Home-based intervention to foster child development improved cognitive and social-emotional scores in infants with IDA, but social-emotional differences remained between infants with IDA and those without IDA.
Authors:
Betsy Lozoff; Julia B Smith; Katy M Clark; Carmen Gloria Perales; Francisca Rivera; Marcela Castillo
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2010-09-20
Journal Detail:
Title:  Pediatrics     Volume:  126     ISSN:  1098-4275     ISO Abbreviation:  Pediatrics     Publication Date:  2010 Oct 
Date Detail:
Created Date:  2010-10-05     Completed Date:  2010-10-27     Revised Date:  2014-09-17    
Medline Journal Info:
Nlm Unique ID:  0376422     Medline TA:  Pediatrics     Country:  United States    
Other Details:
Languages:  eng     Pagination:  e884-94     Citation Subset:  AIM; IM    
Data Bank Information
Bank Name/Acc. No.:
ClinicalTrials.gov/NCT00998998
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MeSH Terms
Descriptor/Qualifier:
Anemia, Iron-Deficiency / therapy*
Child Development*
Community Health Workers*
Ferrous Compounds / therapeutic use
House Calls*
Humans
Infant
Infant Behavior*
Mother-Child Relations*
Single-Blind Method
Grant Support
ID/Acronym/Agency:
HD14122/HD/NICHD NIH HHS; HD33487/HD/NICHD NIH HHS; R01 HD033487/HD/NICHD NIH HHS; R01 HD033487-03/HD/NICHD NIH HHS; R01 HD033487-03S1/HD/NICHD NIH HHS; R01 HD033487-04/HD/NICHD NIH HHS; R01 HD033487-04S1/HD/NICHD NIH HHS; R01 HD033487-05/HD/NICHD NIH HHS; R01 HD033487-06/HD/NICHD NIH HHS; R01 HD033487-07/HD/NICHD NIH HHS; R01 HD033487-08/HD/NICHD NIH HHS; R01 HD033487-09/HD/NICHD NIH HHS; R01 HD033487-10A2/HD/NICHD NIH HHS; R01 HD033487-11/HD/NICHD NIH HHS; R01 HD033487-12/HD/NICHD NIH HHS; R01 HD033487-13/HD/NICHD NIH HHS; R01 HD033487-14/HD/NICHD NIH HHS
Chemical
Reg. No./Substance:
0/Ferrous Compounds; 7720-78-7/ferrous sulfate
Comments/Corrections

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