Document Detail


Home IV Antibiotic Therapy and Exercise Capacity in Children with CF: A Case Series.
MedLine Citation:
PMID:  21448344     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Abstract/OtherAbstract:
PURPOSE: This case series describes the effect of home intravenous (IV) antibiotic therapy on spirometry and exercise capacity in a group of children with cystic fibrosis (CF).
METHODS: Outcomes from 10 children with CF who were prescribed a 14-day course of home IV antibiotics for a respiratory exacerbation are reported. All children performed spirometry and a modified shuttle test (MST) before and after 14-days of home IV therapy.
RESULTS: After 14 days, FEV(1) increased by mean (± SE) 12 ± 4 % (p < 0.05) but mean MST did not improve compared to baseline. All children improved or maintained spirometry values with treatment, however, only 5 improved MST distance.
CONCLUSION: After 14 days of home IV antibiotic therapy, a significant improvement in spirometry, but not exercise capacity, was seen in this small series of children with CF. The lack of improvement in exercise capacity for all children following home IV antibiotic therapy suggests factors other than spirometry determine exercise capacity. Identifying and investigating the factors that influence exercise capacity during home IV antibiotic therapy requires further investigation.
Authors:
Narelle S Cox; Karen O McKay; Jennifer M Follett; Jennifer A Alison
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Cardiopulmonary physical therapy journal     Volume:  22     ISSN:  1541-7891     ISO Abbreviation:  Cardiopulm Phys Ther J     Publication Date:  2011 Mar 
Date Detail:
Created Date:  2011-03-30     Completed Date:  2011-07-14     Revised Date:  2014-07-30    
Medline Journal Info:
Nlm Unique ID:  101155626     Medline TA:  Cardiopulm Phys Ther J     Country:  United States    
Other Details:
Languages:  eng     Pagination:  16-9     Citation Subset:  -    
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