Document Detail

A home-based exercise program to improve function, fatigue, and sleep quality in patients with Stage IV lung and colorectal cancer: a randomized controlled trial.
MedLine Citation:
PMID:  23017624     Owner:  NLM     Status:  MEDLINE    
CONTEXT: Exercise benefits patients with cancer, but studies of home-based approaches, particularly among those with Stage IV disease, remain small and exploratory.
OBJECTIVES: To conduct an adequately powered trial of a home-based exercise intervention that can be facilely integrated into established delivery and reimbursement structures.
METHODS: Sixty-six adults with Stage IV lung or colorectal cancer were randomized, in an eight-week trial, to usual care or incremental walking and home-based strength training. The exercising participants were instructed during a single physiotherapy visit and subsequently exercised four days or more per week; training and step-count goals were advanced during bimonthly telephone calls. The primary outcome measure was mobility assessed with the Ambulatory Post Acute Care Basic Mobility Short Form. Secondary outcomes included ratings of pain and sleep quality as well as the ability to perform daily activities (Ambulatory Post Acute Care Daily Activities Short Form), quality of life (Functional Assessment of Cancer Therapy-General), and fatigue (Functional Assessment of Cancer Therapy-Fatigue).
RESULTS: Three participants dropped out and seven died (five in the intervention and two in the control group, P=0.28). At Week 8, the intervention group reported improved mobility (P=0.01), fatigue (P=0.02), and sleep quality (P=0.05) compared with the usual care group, but did not differ on the other measures.
CONCLUSION: A home-based exercise program seems capable of improving the mobility, fatigue, and sleep quality of patients with Stage IV lung and colorectal cancer.
Andrea L Cheville; Jenny Kollasch; Justin Vandenberg; Tiffany Shen; Axel Grothey; Gail Gamble; Jeffrey R Basford
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural     Date:  2012-09-24
Journal Detail:
Title:  Journal of pain and symptom management     Volume:  45     ISSN:  1873-6513     ISO Abbreviation:  J Pain Symptom Manage     Publication Date:  2013 May 
Date Detail:
Created Date:  2013-05-07     Completed Date:  2013-12-06     Revised Date:  2014-01-23    
Medline Journal Info:
Nlm Unique ID:  8605836     Medline TA:  J Pain Symptom Manage     Country:  United States    
Other Details:
Languages:  eng     Pagination:  811-21     Citation Subset:  IM    
Copyright Information:
Copyright © 2013. Published by Elsevier Inc.
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MeSH Terms
Activities of Daily Living
Colorectal Neoplasms / complications,  pathology,  rehabilitation*
Exercise Therapy / methods*
Fatigue / etiology,  rehabilitation*
Home Care Services
Liver Neoplasms / complications,  pathology,  rehabilitation*
Middle Aged
Neoplasm Staging
Palliative Care / methods*
Quality of Life
Recovery of Function
Sleep Disorders / etiology,  rehabilitation*
Terminal Care / methods
Treatment Outcome
Grant Support

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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