| Holoprosencephaly as a possible embryonic alcohol effect. | |
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MedLine Citation:
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PMID: 1897567 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Three mothers of infants with holoprosencephaly consumed alcohol heavily in pregnancy. We postulate that early alcohol exposure is a possible cause of their malformation. The 3 mothers consumed alcohol only in the first trimester but the first mother continued to take chlordiazepoxide and imipramine throughout the pregnancy. Her infant had an alobar holoprosencephaly associated with a median cleft lip, ocular hypotelorism, and a flat nose. The other infants had semilobar holoprosencephaly and hydrocephalus. These latter 2 infants did not show the characteristic facies of the fetal alcohol syndrome. G-band chromosome studies were normal in all 3 infants. The association of holoprosencephaly with alcohol exposure during pregnancy in humans has been mentioned only briefly, although this malformation has been induced by alcohol in animals. These 3 infants may support the hypothesis that acute or subacute heavy alcohol exposure early in pregnancy could lead to holoprosencephaly without the necessity of a chronic alcohol exposure and without necessarily causing the typical facial findings of the fetal alcohol syndrome. |
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Authors:
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G M Ronen; W L Andrews |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: American journal of medical genetics Volume: 40 ISSN: 0148-7299 ISO Abbreviation: Am. J. Med. Genet. Publication Date: 1991 Aug |
Date Detail:
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Created Date: 1991-10-24 Completed Date: 1991-10-24 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 7708900 Medline TA: Am J Med Genet Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 151-4 Citation Subset: IM |
Affiliation:
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Department of Pediatrics, Memorial University of Newfoundland, St. John's, Canada. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Abnormalities, Drug-Induced* Alcohol Drinking / adverse effects* Chlordiazepoxide / therapeutic use Female Holoprosencephaly / chemically induced*, ultrasonography Humans Imipramine / therapeutic use Maternal-Fetal Exchange Pregnancy Smoking |
| Chemical | |
Reg. No./Substance:
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50-49-7/Imipramine; 58-25-3/Chlordiazepoxide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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