Document Detail


Holding our breath: The emerging and anticipated roles of microRNA in pulmonary hypertension.
MedLine Citation:
PMID:  23130098     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Abstract/OtherAbstract:
Over the past decade, the importance of non-coding RNA such as microRNA has been established in numerous processes that drive human pathogenesis. These crucial molecular regulators modulate networks of target gene transcripts that, in turn, orchestrate cellular phenotypes such as cell survival, differentiation, proliferation, and metabolism among others and thus affect cardiopulmonary vascular disease conditions. Many of these same pathophenotypes figure prominently in the complex pathogenesis of pulmonary hypertension, an enigmatic vascular disorder characterized by a histological panvasculopathy and driven by disparate upstream triggers such as hypoxia, inflammation, and bone morphogenetic protein signaling. Yet, the importance of just a few microRNAs in pulmonary hypertension has been recognized, and we are only beginning to understand the integrative functions of these molecules in this disease. By combining systems biology with traditional experimental approaches, more direct insight into the pleiotropy of microRNA should not only further reveal the spectrum of molecular pathways that cause pulmonary hypertension, but also offer novel and much needed diagnostic and therapeutic strategies.
Authors:
Kevin White; Joseph Loscalzo; Stephen Y Chan
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Pulmonary circulation     Volume:  2     ISSN:  2045-8940     ISO Abbreviation:  Pulm Circ     Publication Date:  2012 Jul 
Date Detail:
Created Date:  2012-11-06     Completed Date:  2012-12-12     Revised Date:  2014-03-18    
Medline Journal Info:
Nlm Unique ID:  101557243     Medline TA:  Pulm Circ     Country:  India    
Other Details:
Languages:  eng     Pagination:  278-90     Citation Subset:  -    
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Descriptor/Qualifier:
Grant Support
ID/Acronym/Agency:
K08 HL096834/HL/NHLBI NIH HHS; P01 HL048743/HL/NHLBI NIH HHS; P50 HL107192/HL/NHLBI NIH HHS; R37 HL061795/HL/NHLBI NIH HHS; U01 HL108630/HL/NHLBI NIH HHS; U54 HL070819/HL/NHLBI NIH HHS
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