Document Detail


Hold or fold - proteins in advanced heart failure and myocardial recovery.
MedLine Citation:
PMID:  25331159     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Advanced heart failure describes the subset of heart failure patients refractory to conventional medical therapy. For some advanced heart failure patients, the use of mechanical circulatory support provides an intermediary "bridge" step for transplant eligible patients or an alternative therapy for transplant ineligible patients. Over the past 20 years, clinical observations have revealed that approximately 1% of patients with mechanical circulatory support undergo significant reverse remodeling to the point where the device can be explanted. Unfortunately, it is unclear why some patients experience durable, sustained myocardial remission, while others re-develop heart failure (i.e. which hearts "hold" and which hearts "fold"). In this review, we outline unmet clinical needs related to treating patients with mechanical circulatory support, provide an overview of protein dynamics in the reverse remodeling process, and propose specific areas where we expect mass spectrometry and proteomic analyses will have significant impact on our understanding of disease progression, molecular mechanisms of recovery, and provide new markers with prognostic value that can positively impact patient care. Complimentary perspectives are provided with the goal of making this important topic accessible and relevant to both a clinical and basic science audience, as the intersection of these disciplines is required to advance the field. This article is protected by copyright. All rights reserved.
Authors:
Claudius Mahr; Rebekah L Gundry
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-10-21
Journal Detail:
Title:  Proteomics. Clinical applications     Volume:  -     ISSN:  1862-8354     ISO Abbreviation:  Proteomics Clin Appl     Publication Date:  2014 Oct 
Date Detail:
Created Date:  2014-10-21     Completed Date:  -     Revised Date:  2014-10-22    
Medline Journal Info:
Nlm Unique ID:  101298608     Medline TA:  Proteomics Clin Appl     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
This article is protected by copyright. All rights reserved.
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