| Hodgkin's disease: a disorder of dysregulated cellular cross-talk. | |
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MedLine Citation:
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PMID: 9592019 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Hodgkin's disease (HD) is a peculiar type of human malignant lymphoma characterized by a very low frequency of tumor cells, the so called Hodgkin and Reed-Sternberg (H-RS) cells, embedded in a hyperplastic background of non-neoplastic (reactive) cells recruited and activated by H-RS cells-derived cytokines. H-RS cells can be functionally regarded as antigen-presenting cells (APC) able to elicit an intense, but anergic and ineffective, T-cell mediated immune response along with a hyperplastic inflammatory reaction which involves several cell types including T- and B-cells, neutrophils, eosinophils, plasma cells, fibroblasts and stromal cells. In tissues involved by HD, malignant H-RS cells and their reactive neighboring cells are able to cross-talk via a complex network of cytokine- and cell contact-dependent interactions. As a result of such interactions, mediated by specific surface receptors and adhesion molecules on both tumor and non-neoplastic cells, H-RS cells may receive several proliferative and anti-apoptotic signals favoring the cellular expansion and tumor cell survival in HD. The ineffective T-cell immune response elicited by the abnormal APC function of H-RS cells may further contribute to the biologic and clinical progression of HD. Innovative therapeutic strategies aimed at blocking the pathways of dysregulated cellular cross-talk among H-RS cells and bystander reactive cell populations might be beneficial in the treatment of HD patients. |
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Authors:
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A Pinto; V Gattei; V Zagonel; D Aldinucci; M Degan; A De Iuliis; F M Rossi; F Tassan Mazzocco; C Godeas; M Rupolo; D Poletto; A Gloghini; A Carbone; H J Gruss |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Biotherapy (Dordrecht, Netherlands) Volume: 10 ISSN: 0921-299X ISO Abbreviation: Biotherapy Publication Date: 1998 |
Date Detail:
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Created Date: 1998-06-26 Completed Date: 1998-06-26 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8903031 Medline TA: Biotherapy Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 309-20 Citation Subset: IM |
Affiliation:
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The Leukemia Unit, I.R.C.C.S., Aviano, Italy. apinto@ets.it |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Cell Communication
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physiology* Hodgkin Disease / pathology* Humans |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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