Document Detail


Hodgkin lymphoma.
MedLine Citation:
PMID:  23023715     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Hodgkin lymphoma (HL), a B cell-derived cancer, is one of the most common lymphomas. In HL, the tumor cells--Hodgkin and Reed-Sternberg (HRS) cells--are usually very rare in the tissue. Although HRS cells are derived from mature B cells, they have largely lost their B cell phenotype and show a very unusual co-expression of markers of various hematopoietic cell types. HRS cells show deregulated activation of multiple signaling pathways and transcription factors. The activation of these pathways and factors is partly mediated through interactions of HRS cells with various other types of cells in the microenvironment, but also through genetic lesions. The transforming events involved in the pathogenesis of HL are only partly understood, but mutations affecting the NF-κB and JAK/STAT pathways are frequent. The dependency of HRS cells on microenvironmental interactions and deregulated signaling pathways may offer novel strategies for targeted therapies.
Authors:
Ralf Küppers; Andreas Engert; Martin-Leo Hansmann
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2012-10-01
Journal Detail:
Title:  The Journal of clinical investigation     Volume:  122     ISSN:  1558-8238     ISO Abbreviation:  J. Clin. Invest.     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-10-01     Completed Date:  2013-02-01     Revised Date:  2013-07-11    
Medline Journal Info:
Nlm Unique ID:  7802877     Medline TA:  J Clin Invest     Country:  United States    
Other Details:
Languages:  eng     Pagination:  3439-47     Citation Subset:  AIM; IM    
Affiliation:
Institute of Cell Biology (Cancer Research), Medical School, University of Duisburg-Essen, Essen, Germany. ralf.kueppers@uk-essen.de
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MeSH Terms
Descriptor/Qualifier:
Antigens, Differentiation, B-Lymphocyte / analysis
Antineoplastic Combined Chemotherapy Protocols / therapeutic use
B-Lymphocytes / pathology
Cell Lineage
Cell Transformation, Neoplastic / genetics
Chemoradiotherapy
Clinical Trials as Topic
Epstein-Barr Virus Infections / pathology
Gene Expression Regulation, Neoplastic
Germ-Line Mutation
Herpesvirus 4, Human / genetics,  pathogenicity
Hodgkin Disease* / classification,  etiology,  genetics,  pathology,  therapy,  virology
Humans
Molecular Targeted Therapy
NF-kappa B / metabolism
Neoplasm Proteins / biosynthesis,  genetics,  physiology
Phenotype
Reed-Sternberg Cells / immunology,  pathology
Signal Transduction / genetics,  physiology
Transcription Factors / genetics,  physiology
Tumor Microenvironment
Tumor Virus Infections / pathology
Chemical
Reg. No./Substance:
0/Antigens, Differentiation, B-Lymphocyte; 0/NF-kappa B; 0/Neoplasm Proteins; 0/Transcription Factors
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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