| Hodgkin lymphoma. | |
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MedLine Citation:
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PMID: 23023715 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Hodgkin lymphoma (HL), a B cell-derived cancer, is one of the most common lymphomas. In HL, the tumor cells--Hodgkin and Reed-Sternberg (HRS) cells--are usually very rare in the tissue. Although HRS cells are derived from mature B cells, they have largely lost their B cell phenotype and show a very unusual co-expression of markers of various hematopoietic cell types. HRS cells show deregulated activation of multiple signaling pathways and transcription factors. The activation of these pathways and factors is partly mediated through interactions of HRS cells with various other types of cells in the microenvironment, but also through genetic lesions. The transforming events involved in the pathogenesis of HL are only partly understood, but mutations affecting the NF-κB and JAK/STAT pathways are frequent. The dependency of HRS cells on microenvironmental interactions and deregulated signaling pathways may offer novel strategies for targeted therapies. |
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Authors:
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Ralf Küppers; Andreas Engert; Martin-Leo Hansmann |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review Date: 2012-10-01 |
Journal Detail:
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Title: The Journal of clinical investigation Volume: 122 ISSN: 1558-8238 ISO Abbreviation: J. Clin. Invest. Publication Date: 2012 Oct |
Date Detail:
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Created Date: 2012-10-01 Completed Date: 2013-02-01 Revised Date: 2013-02-20 |
Medline Journal Info:
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Nlm Unique ID: 7802877 Medline TA: J Clin Invest Country: United States |
Other Details:
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Languages: eng Pagination: 3439-47 Citation Subset: AIM; IM |
Affiliation:
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Institute of Cell Biology (Cancer Research), Medical School, University of Duisburg-Essen, Essen, Germany. ralf.kueppers@uk-essen.de |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Antigens, Differentiation, B-Lymphocyte
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analysis Antineoplastic Combined Chemotherapy Protocols / therapeutic use B-Lymphocytes / pathology Cell Lineage Cell Transformation, Neoplastic / genetics Chemoradiotherapy Clinical Trials as Topic Epstein-Barr Virus Infections / pathology Gene Expression Regulation, Neoplastic Germ-Line Mutation Herpesvirus 4, Human / genetics, pathogenicity Hodgkin Disease* / classification, etiology, genetics, pathology, therapy, virology Humans Molecular Targeted Therapy NF-kappa B / metabolism Neoplasm Proteins / biosynthesis, genetics, physiology Phenotype Reed-Sternberg Cells / immunology, pathology Signal Transduction / genetics, physiology Transcription Factors / genetics, physiology Tumor Microenvironment Tumor Virus Infections / pathology |
| Chemical | |
Reg. No./Substance:
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0/Antigens, Differentiation, B-Lymphocyte; 0/NF-kappa B; 0/Neoplasm Proteins; 0/Transcription Factors |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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