Document Detail

Hiv-specific secretory IgA in breast milk of HIV-positive mothers is not associated with protection against HIV transmission among breast-fed infants.
MedLine Citation:
PMID:  17095329     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: To test whether secretory immunoglobulin A (sIgA) to human immunodeficiency virus (HIV) antigens in breast milk of HIV-positive women is associated with protection against HIV transmission among breast-fed infants.
STUDY DESIGN: Nested, case-control design in which HIV-specific sIgA was measured in breast milk collected from 90 HIV-positive women enrolled in a study in Lusaka, Zambia. Milk samples were selected to include 26 HIV-positive mothers with infected infants (transmitters) and 64 mothers with uninfected infants (nontransmitters).
RESULTS: HIV-specific sIgA was detected more often in breast milk of transmitting mothers (76.9%) than in breast milk of nontransmitting mothers (46.9%, P = .009). There were no significant associations between HIV-specific sIgA in breast milk and other maternal factors, including HIV RNA quantities in breast milk, CD4 count, and plasma RNA quantities.
CONCLUSIONS: HIV-specific sIgA in breast milk does not appear to be a protective factor against HIV transmission among breast-fed infants.
Louise Kuhn; Daria Trabattoni; Chipepo Kankasa; Moses Sinkala; Francesca Lissoni; Mrinal Ghosh; Grace Aldrovandi; Don Thea; Mario Clerici
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of pediatrics     Volume:  149     ISSN:  0022-3476     ISO Abbreviation:  J. Pediatr.     Publication Date:  2006 Nov 
Date Detail:
Created Date:  2006-11-10     Completed Date:  2007-01-04     Revised Date:  2014-09-17    
Medline Journal Info:
Nlm Unique ID:  0375410     Medline TA:  J Pediatr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  611-6     Citation Subset:  AIM; IM    
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MeSH Terms
Antibody Specificity
Biological Markers / blood
Breast Feeding
CD4 Lymphocyte Count
Case-Control Studies
Follow-Up Studies
HIV Infections / epidemiology,  immunology*,  prevention & control*,  transmission
HIV-1 / immunology*
Immunoglobulin A, Secretory / administration & dosage,  immunology*
Infant, Low Birth Weight
Infant, Newborn
Infectious Disease Transmission, Vertical / prevention & control*
Logistic Models
Milk, Human / immunology*
Multivariate Analysis
RNA, Viral / blood
Risk Factors
Viral Load
Grant Support
39611//PHS HHS; 40777//PHS HHS; R01 HD039611/HD/NICHD NIH HHS; R01 HD039611-01/HD/NICHD NIH HHS
Reg. No./Substance:
0/Biological Markers; 0/Immunoglobulin A, Secretory; 0/RNA, Viral
Comment In:
J Pediatr. 2006 Nov;149(5):591-3   [PMID:  17095322 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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