| Hitting their targets: an emerging picture of E2F and cell cycle control. | |
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MedLine Citation:
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PMID: 15380244 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Understanding the role of transcription factors in governing cell-cycle progression in mammalian cells has been hindered until recently by a relative lack of genetic and genomic approaches. New approaches that harness the power of ChIP and combine this technique with DNA microarrays and bioinformatics have identified direct, physiological targets and have significantly altered our view of the E2F transcription factor that is known to play a role in regulation of cell-cycle progression. Further, the identification of additional E2F family members and factors that function in concert with E2F have considerably expanded our picture of the genetic programs that are governed by this essential regulatory factor. |
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Authors:
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Alexandre Blais; Brian David Dynlacht |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.; Review |
Journal Detail:
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Title: Current opinion in genetics & development Volume: 14 ISSN: 0959-437X ISO Abbreviation: Curr. Opin. Genet. Dev. Publication Date: 2004 Oct |
Date Detail:
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Created Date: 2004-09-21 Completed Date: 2005-02-16 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 9111375 Medline TA: Curr Opin Genet Dev Country: England |
Other Details:
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Languages: eng Pagination: 527-32 Citation Subset: IM |
Affiliation:
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Department of Pathology, MSB 504, New York University School of Medicine and NYU Cancer Institute, 550 First Avenue, New York, New York 10016, USA. brian.dynlacht@med.nyu.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Apoptosis Cell Cycle* Cell Cycle Proteins / classification, metabolism* DNA Damage DNA-Binding Proteins / classification, metabolism* E2F Transcription Factors Humans Substrate Specificity Transcription Factors / classification, metabolism* |
| Grant Support | |
ID/Acronym/Agency:
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2 R01 CA77245-07/CA/NCI NIH HHS; GM67132/GM/NIGMS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Cell Cycle Proteins; 0/DNA-Binding Proteins; 0/E2F Transcription Factors; 0/Transcription Factors |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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