| Hitchhiking and associative overdominance at a microsatellite locus. | |
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MedLine Citation:
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PMID: 7739389 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The possible effects of a selected locus on a closely linked microsatellite locus are discussed and analyzed in terms of coalescent theory and models of the mutation process. Background selection caused by recurrent deleterious mutations will reduce the variance of allele size at a microsatellite locus. The occasional substitution of advantageous alleles (genetic hitchhiking) will also reduce the variance, but a high mutation rate at a microsatellite locus can restore the variance relatively rapidly. Overdominance at the selected locus will increase the variance at the microsatellite locus and create partitioning of the variation in allele size among gametes carrying one or the other of the overdominant alleles. These results suggest that neutral microsatellite loci can provide indicators of selective processes at closely linked loci. |
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Authors:
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M Slatkin |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Molecular biology and evolution Volume: 12 ISSN: 0737-4038 ISO Abbreviation: Mol. Biol. Evol. Publication Date: 1995 May |
Date Detail:
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Created Date: 1995-06-07 Completed Date: 1995-06-07 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 8501455 Medline TA: Mol Biol Evol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 473-80 Citation Subset: IM |
Affiliation:
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Department of Integrative Biology, University of California at Berkeley, 94720, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Alleles Chromosome Mapping DNA, Satellite / genetics* Genes, Dominant / genetics Genetic Variation / genetics Linkage (Genetics) Models, Genetic* Mutation |
| Grant Support | |
ID/Acronym/Agency:
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R01-GM40282/GM/NIGMS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/DNA, Satellite |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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