Document Detail

Hit to lead SAR study on benzoxazole derivatives for an NPY Y5 antagonist.
MedLine Citation:
PMID:  22300657     Owner:  NLM     Status:  Publisher    
We report a hit to lead study on a novel benzoxazole NPY Y5 antagonist. Starting from HTS hit 1, structure-activity relationships were developed. Compound 12 showed reduction of food intake and a tendency to suppress body weight gain over the 21-day experimental period.
Naoki Omori; Naoki Kouyama; Akira Yukimasa; Kana Watanabe; Yasunori Yokota; Hideki Tanioka; Hirohide Nambu; Hideo Yukioka; Norihito Sato; Yukari Tanaka; Kazutaka Sekiguchi; Takayuki Okuno
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-1-18
Journal Detail:
Title:  Bioorganic & medicinal chemistry letters     Volume:  -     ISSN:  1464-3405     ISO Abbreviation:  -     Publication Date:  2012 Jan 
Date Detail:
Created Date:  2012-2-3     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9107377     Medline TA:  Bioorg Med Chem Lett     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012 Elsevier Ltd. All rights reserved.
Medicinal Research Laboratories, Shionogi & Co., Ltd, 1-1, Futaba-cho 3-chome, Toyonaka, Osaka 561-0825, Japan.
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