Document Detail

History of weight cycling does not impede future weight loss or metabolic improvements in postmenopausal women.
MedLine Citation:
PMID:  22898251     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: Given that the repetitive loss and regain of body weight, termed weight cycling, is a prevalent phenomenon that has been associated with negative physiological and psychological outcomes, the purpose of this study was to investigate weight change and physiological outcomes in women with a lifetime history of weight cycling enrolled in a 12-month diet and/or exercise intervention.
METHODS: 439 overweight, inactive, postmenopausal women were randomized to: i) dietary weight loss with a 10% weight loss goal (N=118); ii) moderate-to-vigorous intensity aerobic exercise for 45 min/day, 5 days/week (n=117); ii) both dietary weight loss and exercise (n=117); or iv) control (n=87). Women were categorized as non-, moderate- (≥3 losses of ≥4.5 kg), or severe-cyclers (≥3 losses of ≥9.1 kg). Trend tests and linear regression were used to compare adherence and changes in weight, body composition, blood pressure, insulin, C-peptide, glucose, insulin resistance (HOMA-IR), C-reactive protein, leptin, adiponectin, and interleukin-6 between cyclers and non-cyclers.
RESULTS: Moderate (n=103) and severe (n=77) cyclers were heavier and had less favorable metabolic profiles than non-cyclers at baseline. There were, however, no significant differences in adherence to the lifestyle interventions. Weight-cyclers (combined) had a greater improvement in HOMA-IR compared to non-cyclers participating in the exercise only intervention (P=.03), but no differences were apparent in the other groups.
CONCLUSION: A history of weight cycling does not impede successful participation in lifestyle interventions or alter the benefits of diet and/or exercise on body composition and metabolic outcomes.
Caitlin Mason; Karen E Foster-Schubert; Ikuyo Imayama; Liren Xiao; Angela Kong; Kristin L Campbell; Catherine R Duggan; Ching-Yun Wang; Catherine M Alfano; Cornelia M Ulrich; George L Blackburn; Anne McTiernan
Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2012-08-14
Journal Detail:
Title:  Metabolism: clinical and experimental     Volume:  62     ISSN:  1532-8600     ISO Abbreviation:  Metab. Clin. Exp.     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2012-12-11     Completed Date:  2013-05-03     Revised Date:  2014-05-30    
Medline Journal Info:
Nlm Unique ID:  0375267     Medline TA:  Metabolism     Country:  United States    
Other Details:
Languages:  eng     Pagination:  127-36     Citation Subset:  IM    
Copyright Information:
Copyright © 2013 Elsevier Inc. All rights reserved.
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MeSH Terms
Adiponectin / blood
Blood Glucose / metabolism
Blood Pressure / physiology
Body Composition / physiology
C-Peptide / blood
C-Reactive Protein / metabolism
Diet, Reducing*
Insulin / blood
Insulin Resistance / physiology
Interleukin-6 / blood
Leptin / blood
Linear Models
Middle Aged
Overweight / metabolism
Postmenopause / metabolism*
Weight Gain / physiology*
Weight Loss / physiology*
Grant Support
2R25CA057699-16/CA/NCI NIH HHS; 5KL2RR025015-03/RR/NCRR NIH HHS; KL2 RR025015/RR/NCRR NIH HHS; R01 CA102504/CA/NCI NIH HHS; R01 CA105204/CA/NCI NIH HHS; R25 CA057699/CA/NCI NIH HHS; R25 CA094880/CA/NCI NIH HHS; R25 CA94880/CA/NCI NIH HHS; U54 CA116847/CA/NCI NIH HHS; U54-CA116847/CA/NCI NIH HHS; //Canadian Institutes of Health Research
Reg. No./Substance:
0/Adiponectin; 0/Blood Glucose; 0/C-Peptide; 0/Insulin; 0/Interleukin-6; 0/Leptin; 9007-41-4/C-Reactive Protein
Comment In:
Climacteric. 2013 Feb;16(1):198-9   [PMID:  23437450 ]

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