Document Detail

History of non-fatal cardiovascular disease in a cohort of Dutch and British patients with haemophilia.
MedLine Citation:
PMID:  22775476     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: Cardiovascular disease (CVD) mortality is reported to be lower in haemophilia patients than in the general population, but information on the occurrence of non-fatal CVD is lacking. The aim of our study was to assess CVD history in a cohort of living haemophilia patients.
METHODS: Retrospective data on the occurrence of myocardial infarction, angina pectoris, ischaemic stroke and intracranial bleeding in 709 living Dutch and British haemophilia patients aged 30 yr or older were analysed and compared with the general age-matched male population.
RESULTS: There was a trend towards a lower cumulative incidence of myocardial infarction (1.7% vs. 4.0%) and ischaemic stroke (0% vs. 1.5%) in patients with severe haemophilia than in the general population, while the occurrence of angina pectoris was similar (3.2 vs. 3.7%). As expected, the cumulative incidence of intracranial bleeding was, on the other hand, significantly increased in haemophilia patients (1.6% vs. 0.4% in the general population).
CONCLUSION: Our results suggest a protective effect of severe haemophilia against acute ischaemic CVD.
Dietje E Fransen van de Putte; Kathelijn Fischer; Michael Makris; R Campbell Tait; Pratima Chowdary; Peter W Collins; Karina Meijer; Goris Roosendaal; Roger E G Schutgens; Eveline P Mauser-Bunschoten
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2012-08-03
Journal Detail:
Title:  European journal of haematology     Volume:  89     ISSN:  1600-0609     ISO Abbreviation:  Eur. J. Haematol.     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-09-14     Completed Date:  2012-11-13     Revised Date:  2013-03-04    
Medline Journal Info:
Nlm Unique ID:  8703985     Medline TA:  Eur J Haematol     Country:  England    
Other Details:
Languages:  eng     Pagination:  336-9     Citation Subset:  IM    
Copyright Information:
© 2012 John Wiley & Sons A/S.
Van Creveldkliniek, Department of Haematology, University Medical Center Utrecht, Utrecht, The Netherlands.
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MeSH Terms
Aged, 80 and over
Cardiovascular Diseases / complications*
Cohort Studies
Great Britain
Hemophilia A / complications*
Middle Aged

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