Document Detail


History of gestational hypertension is associated with the metabolic syndrome and masked hypertension but not arterial stiffness in women with essential hypertension.
MedLine Citation:
PMID:  18174767     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The underlying mechanisms of subsequent increased risk of cardiovascular disease with a history of gestational hypertension (GH) are not known. Untreated hypertensive women (n=155, age 43+/-1 years) underwent ambulatory blood pressure (BP) monitoring and assessment of aortic pulse wave velocity (PWV) and augmentation index (AIx). Despite identical clinic BP readings, the group of women with GH (n=54) had higher (P=.002) ambulatory daytime systolic BP levels and a greater number of extreme nocturnal dippers (P=.005) than the group without GH. Women with GH had higher body mass index (P=.003), greater waist circumference (P=.02), higher levels of triglycerides (P=.002), lower levels of high-density lipoprotein cholesterol (P=.004), a higher prevalence of the metabolic syndrome (P<.05) and microalbuminuria (P=.004), higher plasma renin activity (P=.03), and higher aldosterone levels (P=.01). There was no significant difference in PWV and AIx between the 2 groups. The higher prevalence of the metabolic syndrome, microalbuminuria, masked hypertension, and activation of the renin-angiotensin-aldosterone system but not arterial stiffness may explain the subsequent propensity to high BP and cardiovascular disease in women with GH.
Authors:
Azra Mahmud; Mehnaz Jatoi; Yei Roi Chee; John Feely
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Journal of clinical hypertension (Greenwich, Conn.)     Volume:  10     ISSN:  1524-6175     ISO Abbreviation:  J Clin Hypertens (Greenwich)     Publication Date:  2008 Jan 
Date Detail:
Created Date:  2008-01-04     Completed Date:  2008-03-04     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100888554     Medline TA:  J Clin Hypertens (Greenwich)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  21-6     Citation Subset:  IM    
Affiliation:
Department of Pharmacology and Therapeutics, Trinity College, Dublin, Ireland. mahmuda@tcd.ie
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MeSH Terms
Descriptor/Qualifier:
Adult
Arteries / pathology*
Body Mass Index
Cross-Sectional Studies
Elasticity
Female
Humans
Hypertension / epidemiology*,  pathology,  physiopathology*
Hypertension, Pregnancy-Induced / epidemiology*
Metabolic Syndrome X / epidemiology*
Middle Aged
Pregnancy
Renin-Angiotensin System / physiology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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